Prenatal growth restraint followed by catch-up of weight:: a hyperinsulinemic pathway to polycystic ovary syndrome
Prenatal growth restraint followed by catch-up of weight:: a hyperinsulinemic pathway to polycystic ovary syndrome
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DOI：
10.1016/j.fertnstert.2006.03.013
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发表时间：
2006-07-01
影响因子：
6.7
通讯作者：
Ibanez, Lourdes
中科院分区：
文献类型：
--
作者：
de Zegher, Francis;Ibanez, Lourdes
多囊卵巢综合症 (PCOS) 的发病途径之一始于生命早期的产前生长抑制，随后是婴儿期体重追赶。这一序列导致儿童中期处于 PCOS 前状态，包括高胰岛素血症、低度促炎状态、肾上腺初现增强（有或没有性早熟的阴毛）和脂肪身体成分，即使没有肥胖。这种 PCOS 前期和 PCOS 的变体对二甲双胍的干预反应良好。
One of the pathways to polycystic ovary syndrome (PCOS) starts with an early-life sequence of prenatal growth restraint followed by catch-up of weight during infancy. This sequence results by mid-childhood in a pre-PCOS state including hyperinsulinemia, a low-grade proinflammatory state, an amplified adrenarche (with or without precocious pubarche) and an adipose body composition even in the absence of obesity. This variant of pre-PCOS and PCOS responds well to intervention with metformin.