Treatment of boar sperm with nanoparticles for improved fertility
Treatment of boar sperm with nanoparticles for improved fertility
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DOI：
10.1016/j.theriogenology.2019.05.040
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发表时间：
2019-10-01
期刊：
影响因子：
2.8
通讯作者：
Ryan, Peter L.
中科院分区：
文献类型：
--
作者：
Feugang, Jean M.;Rhoads, Carley E.;Ryan, Peter L.
纳米科学的不断进步已经允许合成各种纳米级颗粒，称为纳米颗粒或纳米材料，通过利用独特的物理化学性质，对于多种生物应用至关重要。尽管在各种体外和体内研究中发现了纳米颗粒的毒性（纳米毒性），但它们的生物相容性和与单细胞和多细胞生物体的有效相互作用的精心设计已经允许它们在研究和生物医学的几个领域中使用。在兽医科学（包括生殖生物学）中合成和应用的各种纳米颗粒已显示出影响动物生产系统常规实践的潜力。这些措施包括精液采集后的操作和高质量精子的保护，以延长其保存期，并改善精子相关的生物技术，如精子介导的基因转移，精子分选，性别分选和冷冻保存。因此，将基于纳米技术的工具应用于精液可能会增强用于生物医学应用的辅助生殖技术，并提高农民的经济生产力。在这里，我们回顾了现有的技术和新兴的工具，纳米技术，可能是有用的，进一步选择高品质的公猪精子和生产力的提高。(C)2019爱思唯尔公司All rights reserved.
Continuous progress in nanoscience has allowed the synthesis of various nanoscale particles, known as nanoparticles or nanomaterials which, by harnessing unique physico-chemical properties, are crucial for multiple bio-applications. Despite the revealed toxicity (nanotoxicity) of nanoparticles in various in vitro and in vivo studies, their careful design for biocompatibility and effective interactions with single-celled and multi-cellular organisms has permitted their use in several fields of research and biomedicine. The various nanoparticles synthesized and applied in the veterinary sciences, including reproductive biology, have shown potential to influence routine practices in animal production systems. These include post-collection manipulation of semen and the protection of high-quality spermatozoa to extend their preservation, and to improve sperm-related biotechnologies such as sperm-mediated gene transfer, sperm sorting, sex-sorting, and cryopreservation. Therefore, the application of nanotechnology-based tools to semen may enhance assisted reproductive technologies for biomedical applications and improve economic productivity for farmers. Here, we review the efficacy of available techniques and emerging tools of nanotechnology that might be useful for further selection of high quality boar spermatozoa and productivity improvement. (C) 2019 Elsevier Inc. All rights reserved.