The unnamed complex: what do we know about Smc5-Smc6?
The unnamed complex: what do we know about Smc5-Smc6?
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DOI：
10.1007/s10577-008-9016-8
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发表时间：
2009-02-01
影响因子：
2.6
通讯作者：
Aragon, Luis
中科院分区：
文献类型：
--
作者：
De Piccoli, Giacomo;Torres-Rosell, Jordi;Aragon, Luis
染色体结构维持蛋白（SMC）构成了参与染色体代谢的三种蛋白质复合物的核心：粘着蛋白、凝聚蛋白和Smc 5-Smc 6复合物。虽然已经分别描述了粘连蛋白和凝聚蛋白在姐妹染色单体粘连和染色体凝聚中的作用，但Smc 5-Smc 6的细胞功能尚未了解，因此名称描述性较低。该复合物参与多种DNA修复途径。它包含的活性使人联想到那些描述的凝聚素和凝聚素，以及几个DNA解旋酶和核酸内切酶。它是姐妹染色单体重组所必需的，并且smc 5-smc 6突变体遭受非程序重组中间体的积累。该复合物含有SUMO连接酶和潜在的泛素连接酶;因此Smc 5-Smc 6目前可能有一个沉闷的名字，但它似乎注定要被认为是维持染色体稳定性的关键角色。在这篇综述中，我们总结了我们目前对这种神秘的蛋白质复合物的理解。
The structural maintenance of chromosome (SMC) proteins constitute the cores of three protein complexes involved in chromosome metabolism; cohesin, condensin and the Smc5-Smc6 complex. While the roles of cohesin and condensin in sister chromatid cohesion and chromosome condensation respectively have been described, the cellular function of Smc5-Smc6 is as yet not understood, consequently the less descriptive name. The complex is involved in a variety of DNA repair pathways. It contains activities reminiscent of those described for cohesin and condensin, as well as several DNA helicases and endonucleases. It is required for sister chromatid recombination, and smc5-smc6 mutants suffer from the accumulation of unscheduled recombination intermediates. The complex contains a SUMO-ligase and potentially an ubiquitin-ligase; thus Smc5-Smc6 might presently have a dull name, but it seems destined to be recognized as a key player in the maintenance of chromosome stability. In this review we summarize our present understanding of this enigmatic protein complex.