Monitoring tissue oxygen availability with near infrared spectroscopy (NIRS) in health and disease
Monitoring tissue oxygen availability with near infrared spectroscopy (NIRS) in health and disease
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DOI：
10.1034/j.1600-0838.2001.110404.x
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发表时间：
2001-08-01
影响因子：
4.1
通讯作者：
Kjær, M
中科院分区：
文献类型：
--
作者：
Boushel, R;Langberg, H;Kjær, M
近红外光谱（NIRS）是一种广泛应用的无创测量组织氧（Oz）状态的研究仪器，连续光谱仪是最常用的设备，它可以半定量地测量小血管中氧合血红蛋白和脱氧血红蛋白的变化（小动脉、毛细血管和小静脉），近红外光谱仪硬件的改进和光吸收信号的去卷积算法提高了细胞色素氧化酶测量的分辨率和有效性。近红外光谱已被应用于测量各种组织中的氧合，包括肌肉，大脑和结缔组织，最近它已被用于临床环境中，以评估循环和代谢异常。血流的定量测量也可以使用近红外光谱和光吸收示踪剂，其可以应用于评估循环系统对运动的反应，沿着组织O-2饱和度的评估。可以通过应用静脉阻塞并测量氧合血红蛋白与总血红蛋白的变化，使用NIRS来估计小静脉O-2饱和度。这些不同的测量提供了机会，以评估几个重要的代谢和循环模式在非常局部的组织区域，并可能是富有成效的职业综合征和各种疾病的研究。
Near infrared spectroscopy (NIRS) is becoming a widely used research instrument to measure tissue oxygen (Oz) status non-invasively, Continuous-wave spectrometers are the most commonly used devices, which provide semiquantitative changes in oxygenated and deoxygenated hemoglobin in small blood vessels (arterioles, capillaries and venules), Refinement of NIRS hardware and the algorithms used to deconvolute the light absorption signal have improved the resolution and validity of cytochrome oxidase measurements. NIRS has been applied to measure oxygenation in a variety of tissues including muscle, brain and connective tissue, and more recently it has been used in the clinical setting to assess circulatory and metabolic abnormalities. Quantitative measures of blood flow are also possible using NIRS and a light-absorbing tracer, which can be applied to evaluate circulatory responses to exercise along with the assessment of tissue O-2 saturation. The venular O-2 saturation can be estimated with NIRS by applying venous occlusion and measuring changes in oxygenated vs. total hemoglobin. These various measurements provide the opportunity to evaluate several important metabolic and circulatory patterns in very localized regions of tissue and may be fruitful in the study of occupational syndromes and a variety of diseases.