Novel synthesis and characterization of an AB-type carbonate-substituted hydroxyapatite
Novel synthesis and characterization of an AB-type carbonate-substituted hydroxyapatite
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DOI：
10.1002/jbm.10044
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发表时间：
2002-03-15
期刊：
影响因子：
--
通讯作者：
Bonfield, W
中科院分区：
文献类型：
--
作者：
Gibson, IR;Bonfield, W
本文提出了一种新的合成方法，即在碳酸根存在下，通过水相沉淀法制备出Ca/P摩尔比大于1.67的磷酸钙磷灰石（HA），从而制备出高纯度的混合AB型碳酸根取代羟基磷灰石（CHA）。将所得富钙碳酸盐-磷灰石在二氧化碳气氛中烧结/热处理以产生单相结晶碳酸盐取代的羟基磷灰石。与先前制备B-或AB-型碳酸盐取代的羟基磷灰石的方法相反，在最终产物中不存在钠或铵离子，所述钠或铵离子将存在于来自通常用作碳酸根离子源的碳酸钠或碳酸铵的反应混合物中。用X射线荧光和X射线衍射分别表征了碳酸根取代羟基磷灰石的化学组成和物相组成，用C-H-N分析和傅里叶变换红外光谱分别研究了碳酸根取代羟基磷灰石的程度和性质。与化学计量的HA相比，碳酸盐取代改善了羟基磷灰石的致密化，并将实现接近全密度所需的烧结温度降低了约200 ℃。初步研究表明，这些碳酸盐取代的羟基磷灰石相比化学计量的羟基磷灰石具有改善的机械和生物性能。(C)John Wiley Sons，Inc.
A novel synthesis route has been developed to produce a high-purity mixed AB-type carbonate-substituted hydroxyapatite (CHA) with a carbonate content that is comparable to the type and level observed in bone mineral. This method involves the aqueous precipitation in the presence of carbonate ions in solution of a calcium phosphate apatite with a Ca/P molar ratio greater than the stoichiometric value of 1.67 for hydroxyapatite (HA). The resulting calcium-rich carbonate-apatite is sintered/heat-treated in a carbon dioxide atmosphere to produce a single-phase, crystalline carbonate-substituted hydroxyapatite. In contrast to previous methods for producing B- or AB-type carbonate-substituted hydroxyapatites, no sodium or ammonium ions, which would be present in the reaction mixture from the sodium or ammonium carbonates commonly used as a source of carbonate ions, were present in the final product. The chemical and phase compositions of the carbonate-substituted hydroxyapatite was characterized by X-ray fluorescence and X-ray diffraction, respectively, and the level and nature of the carbonate substitution were studied using C-H-N analysis and Fourier transform infrared spectroscopy, respectively. The carbonate substitution improves the densification of hydroxyapatite and reduces the sintering temperature required to achieve near-full density by approximately 200 degreesC compared to stoichiometric HA. Initial studies have shown that these carbonate-substituted hydroxyapatites have improved mechanical and biologic properties compared to stoichiometric hydroxyapatite. (C) 2001 John Wiley Sons, Inc.