SAND: a Screening for Aphasia in NeuroDegeneration. Development and normative data
SAND: a Screening for Aphasia in NeuroDegeneration. Development and normative data
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DOI：
10.1007/s10072-017-3001-y
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发表时间：
2017-08-01
影响因子：
3.3
通讯作者：
Garrard, Peter
中科院分区：
文献类型：
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作者：
Catricala, Eleonora;Gobbi, Elena;Garrard, Peter
语言评估在神经退行性疾病的临床诊断中具有关键作用，特别是在原发性进行性失语症（PPA）的情况下。目前的诊断标准（Gorno-Tempini等，2011）根据脑萎缩的临床特征和模式确定三种主要变体。广泛接受的工具，诊断，临床分类，并跟进的异质性语言配置文件的PPA仍然缺乏。在这项研究中，我们开发了一个筛选电池，由九个测试（图片命名，单词和句子理解，单词和句子重复，阅读，语义联想，写作和图片描述），以下的建议，目前的诊断指南，并考虑到最近的研究主题。所有的任务都是考虑到心理语言学因素，可以影响性能，实现敏感性的语言缺陷，每个任务相关的目的，并允许识别的选择性特征损伤的每个PPA的变体。134名意大利受试者的规范性数据汇总在同质亚组的年龄，性别和教育的报告。虽然仍需要进一步的工作，但该电池代表了迈向简洁的多语言标准语言检查的第一步，这是一种快速简单的工具，可帮助临床医生和研究人员诊断PPA。
Language assessment has a critical role in the clinical diagnosis of neurodegenerative diseases, in particular, in the case of Primary Progressive Aphasia (PPA). The current diagnostic criteria (Gorno-Tempini et al., 2011) identify three main variants on the basis of clinical features and patterns of brain atrophy. Widely accepted tools to diagnose, clinically classify, and follow up the heterogeneous language profiles of PPA are still lacking. In this study, we develop a screening battery, composed of nine tests (picture naming, word and sentence comprehension, word and sentence repetition, reading, semantic association, writing and picture description), following the recommendations of current diagnostic guidelines and taking into account recent research on the topic. All tasks were developed with consideration of the psycholinguistic factors that can affect performance, with the aim of achieving sensitivity to the language deficit to which each task was relevant, and to allow identification of the selective characteristic impairments of each PPA variant. Normative data on 134 Italian subjects pooled across homogeneous subgroups for age, sex, and education are reported. Although further work is still needed, this battery represents a first step towards a concise multilingual standard language examination, a fast and simple tool to help clinicians and researchers in the diagnosis of PPA.