Cholecystectomy as a risk factor of metabolic syndrome: from epidemiologic clues to biochemical mechanisms
Cholecystectomy as a risk factor of metabolic syndrome: from epidemiologic clues to biochemical mechanisms
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胆囊切除术作为代谢综合征的危险因素：从流行病学线索到生化机制
DOI：
10.1038/labinvest.2017.95
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发表时间：
2018-01-01
影响因子：
5
通讯作者：
Tian, Yu
中科院分区：
文献类型：
--
作者：
Chen, Yongsheng;Wu, Shuodong;Tian, Yu
长期以来，胆囊切除术被认为是一种安全的手术，对身体没有有害影响。然而，最近的研究提供了将胆囊切除术与代谢综合征（MetS）高风险联系起来的线索。在这篇综述中，我们描述了胆囊切除术与代谢综合征相关的流行病学证据。代谢综合征的各个组成部分进行了调查，包括内脏肥胖，血脂异常，血压升高，空腹血糖受损，胰岛素抵抗。在实验研究的基础上，对胆囊切除术后代谢综合征的可能机制进行了讨论。
Cholecystectomy has long been regarded as a safe procedure with no deleterious influence on the body. However, recent studies provide clues that link cholecystectomy to a high risk for metabolic syndrome (MetS). In the present review, we describe the epidemiologic evidence that links cholecystectomy to MetS. Various components of MetS are investigated, including visceral obesity, dyslipidemia, elevated blood pressure, impaired fasting glucose, and insulin resistance. The possible mechanisms that associate cholecystectomy with MetS are discussed on the basis of experimental studies.