Highly Enantioselective Organocatalytic α-Sulfenylation of Azlactones
Highly Enantioselective Organocatalytic α-Sulfenylation of Azlactones
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DOI：
10.1021/ol403303k
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发表时间：
2014-02-07
期刊：
影响因子：
5.2
通讯作者：
Jiang, Zhiyong
中科院分区：
文献类型：
--
作者：
Qiao, Baokun;Liu, Xinfei;Jiang, Zhiyong
The first asymmetric alpha-sulfenylation of azlactones with N-(sulfanyl)succinimides has been developed by using cinchona alkaloid-derived squaramide as a catalyst and 4 angstrom molecular sieves as an additive. The reaction conditions were suitable to 4-alkyl and benzyl-substituted azlactones as well as N-(benzyl/alkyl/arylthio)succinimides, affording adducts with high enantioselectivities (81-94% ee).
