Effects of Short-Term Hypothermal and Contrast Exposure on Immunophysiological Parameters of Laboratory Animals
Effects of Short-Term Hypothermal and Contrast Exposure on Immunophysiological Parameters of Laboratory Animals
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DOI：
10.1007/s10517-009-0566-3
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发表时间：
2009-05-01
影响因子：
0.7
通讯作者：
Besedin, I. M.
中科院分区：
文献类型：
--
作者：
Kalenova, L. F.;Fisher, T. A.;Besedin, I. M.
对近交系动物的实验表明，短期暴露在冷水中可以显著改变免疫系统不同组织水平的结构和功能参数，从骨髓造血到免疫应答抗原的效应阶段。热因素引起免疫系统的非特异性和特异性机制的变化。低温暴露（7-9℃，5秒）增加胸腺指数和骨髓淋巴细胞计数，降低吸收能力，刺激吞噬细胞的代谢活性，刺激细胞介导和抑制体液免疫。对比暴露在冷水和热水（7-9摄氏度，5秒/40-42摄氏度，30秒）中，骨髓单核细胞计数增加，外周血单核细胞计数减少，吞噬细胞代谢活性降低，刺激细胞介导和抑制体液免疫。这些数据证明了体温调节和免疫系统之间相互作用的生理机制。
Experiments on inbred animals showed that short-term exposure in cold water significantly modified structural and functional parameters of the immune system at different levels of its organization, from bone marrow hemopoiesis to effector stage of the immune response to antigen. The thermal factor caused changes in nonspecific and specific mechanisms of the immune system. Hypothermal exposure (7-9 degrees C, 5 sec) increased the thymic index and bone marrow lymphocyte count, reduced absorption capacity and stimulated metabolic activity of phagocytes, stimulated cell-mediated and suppressed humoral immunity. Contrast exposure in cold and hot water (7-9 degrees C, 5 sec/40-42 degrees C, 30 sec) increased monocyte count in bone marrow and reduced it in the their peripheral blood, reduced metabolic activity of phagocytes, stimulated cell-mediated and suppressed humoral immunity. These data demonstrate physiological mechanisms of interactions between the thermoregulatory and immune systems.