Enhanced recovery of human spinothalamic function is associated with central neuropathic pain after SCI
Enhanced recovery of human spinothalamic function is associated with central neuropathic pain after SCI
复制标题
DOI：
10.1016/j.expneurol.2008.12.018
复制
发表时间：
2009-04-01
影响因子：
5.3
通讯作者：
Halder, Pascal
中科院分区：
文献类型：
--
作者：
Hari, Annegret R.;Wydenkeller, Susanne;Halder, Pascal
脊髓丘脑束 (STT) 功能障碍似乎与脊髓损伤 (SCI) 后中枢神经病理性疼痛 (NP) 的发生密切相关。然而，之前试图确定有和没有 NP 的受试者之间 STT 损伤的程度或位置的差异的尝试失败了。在这里，我们表明，与未受影响的受试者相比，患有 NP 的受试者的人类 STT 功能（SCI 后第一年内）的自发恢复有所增强。此外，当前疼痛强度（SCI后平均评估5年）与功能恢复程度之间的相关性证实了STT功能恢复与NP发生之间的密切关系。这些发现有助于更好地理解 SCI 后 NP 生成的机制。 (c) 2009 Elsevier Inc. 保留所有权利。
Spinothalamic tract (STT) dysfunction seems to be crucially involved in the development of central neuropathic pain (NP) after spinal cord injury (SCI). However, previous attempts to identify differences in the extent or location of STT damage between subjects with and without NP failed. Here we show that the spontaneous recovery of human STT function (within the first year after SCI) in subjects suffering NP is enhanced compared to those not affected. Furthermore, the correlation between current pain intensity (assessed on average 5 years after SCI) and extent of functional recovery substantiates the close relationship between recovery of STT function and the occurrence of NP. These findings contribute to a better understanding of mechanisms involved in the generation of NP after SCI. (c) 2009 Elsevier Inc. All rights reserved.