Food Insecurity Is Associated With Inflammation Among Women Living With HIV
Food Insecurity Is Associated With Inflammation Among Women Living With HIV
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DOI：
10.1093/infdis/jiy511
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发表时间：
2019-02-01
影响因子：
6.4
通讯作者：
Weiser, Sheri D.
中科院分区：
文献类型：
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作者：
Leddy, Anna M.;Roque, Annelys;Weiser, Sheri D.
背景。慢性炎症与艾滋病定义和非艾滋病定义相关。有限的研究考虑了粮食不安全如何影响人类免疫缺陷病毒（HIV）感染者的慢性炎症。我们研究了食品不安全是否与美国感染艾滋病毒（WWH）的女性中较高水平的炎症有关。我们分析了2015年收集的来自妇女跨机构艾滋病毒研究中抗逆转录病毒治疗的421名参与者的横断面数据。暴露的是任何食品不安全。结果是炎症，通过促炎细胞因子白介素-6 （IL-6）和肿瘤坏死因子受体1 （TNFR1）水平来衡量。我们进行了多变量线性回归，调整了社会人口统计学、临床和营养因素。近三分之一的参与者（31%）粮食不安全，79%的病毒受到抑制（< 20拷贝/毫升）。在调整分析中，粮食不安全与IL-6水平的1.23倍（95%置信区间[CI]， 1.061.44）和TNFR1水平的1.13倍（95% CI, 1.051.21）相关。在调整后的分层分析中，结果与HIV控制（CD4细胞计数为500个/毫米(3)或不为病毒抑制）没有差异。无论HIV是否得到控制，食物不安全与WWH中的炎症升高有关。研究结果支持有必要制定解决世界卫生组织粮食不安全问题的计划。在美国感染艾滋病毒的女性样本中，食品不安全与促炎细胞因子白介素-6和肿瘤坏死因子受体1水平升高有关，而与艾滋病毒控制无关。
Background. Chronic inflammation is associated with AIDS-defining and non-AIDSdefining conditions. Limited research has considered how food insecurity influences chronic inflammation among people living with human immunodeficiency virus (HIV). We examined whether food insecurity was associated with higher levels of inflammation among women living with HIV (WWH) in the United States.We analyzed cross-sectional data collected in 2015 from 421 participants on antiretroviral therapy from the Womens Interagency HIV Study. The exposure was any food insecurity. The outcome was inflammation, measured by proinflammatory cytokine interleukin-6 (IL-6) and tumor necroses factor receptor 1 (TNFR1) levels. We conducted multivariable linear regressions, adjusting for sociodemographic, clinical, and nutritional factors.Nearly one-third of participants (31%) were food insecure and 79% were virally suppressed (< 20 copies/mL). In adjusted analyses, food insecurity was associated with 1.23 times the level of IL-6 (95% confidence interval [CI], 1.061.44) and 1.13 times the level of TNFR1 (95% CI, 1.051.21). Findings did not differ by HIV control (virally suppressed with CD4 counts 500 cells/mm(3) or not) in adjusted stratified analyses.Food insecurity was associated with elevated inflammation among WWH regardless of HIV control. Findings support the need for programs that address food insecurity among WWH.Among a sample of women living with HIV in the United States, food insecurity was associated with elevated levels of proinflammatory cytokines interleukin-6 and tumor necrosis factor receptor 1, regardless of HIV control.