Viability of a capsule- and lipopolysaccharide-deficient mutant of Neisseria meningitidis
Viability of a capsule- and lipopolysaccharide-deficient mutant of Neisseria meningitidis
复制标题
DOI：
10.1128/iai.73.9.6194-6197.2005
复制
发表时间：
2005-09-01
影响因子：
3.1
通讯作者：
Tommassen, J
中科院分区：
文献类型：
--
作者：
Bos, MP;Tommassen, J
脑膜炎奈瑟菌是唯一一种产生内毒素(LPS)的革兰氏阴性细菌，被证明在没有内毒素的情况下也能存活。这一不寻常的特征被认为是有壳多糖存在所必需的。然而，我们现在表明，在脑膜炎奈瑟氏菌中，维持内毒素缺乏不需要被膜基因簇的任何部分。
Neisseria meningitidis is the only lipopolysaccharide (LPS)-producing gram-negative bacterial species shown to be viable also without LPS. It was thought that the presence of capsular polysaccharide is necessary for this unusual feature. However, we show now that no part of the capsule gene cluster is required for maintaining LPS deficiency in N. meningitidis.