TFF3 induced Fos protein expression in the magnocellular oxytocin neurons of the hypothalamus
TFF3 induced Fos protein expression in the magnocellular oxytocin neurons of the hypothalamus
复制标题
DOI：
10.1016/j.peptides.2003.11.020
复制
发表时间：
2004-05-01
期刊：
影响因子：
3
通讯作者：
Ludwig, M
中科院分区：
文献类型：
--
作者：
Derbyshire, A;Ludwig, M
TFF3 在大鼠和人下丘脑的视上核 (SON) 和室旁核 (PVN) 的大细胞催产素神经元中合成。在这里，我们研究了脑室内 (i.c.v.) 注射 TFF3 是否会刺激催产素释放到血液中并激活大鼠 SON 和 PVN 催产素神经元中的 Fos 蛋白免疫反应性。结果表明，静脉注射后血浆催产素浓度没有改变。注射 TFF3 或媒介物。注射 TFF3 后，SON 和 PVN 中的 Fos 蛋白表达均显着增加，双标记研究表明 Fos 信号主要存在于催产素神经元中。 (C) 2004 Elsevier Inc. 保留所有权利。
TFF3 is synthesized in magnocellular oxytocin neurons of the supraoptic (SON) and paraventricular nuclei (PVN) of the rat and human hypothalamus. Here we investigated whether intracerebroventricular (i.c.v.) injection of TFF3 stimulates oxytocin release into the blood and activates Fos protein immunoreactivity in oxytocin neurons of the SON and PVN in rats. The results show that plasma oxytocin concentrations were not altered after i.c.v. injection of TFF3 or vehicle. Fos protein expression was significantly increased in both the SON and PVN after TFF3 injections and double labeling studies showed that the Fos signal was predominately in oxytocin neurons. (C) 2004 Elsevier Inc. All rights reserved.