Glycosylation Is a Major Regulator of Phenylpropanoid Availability and Biological Activity in Plants.
Glycosylation Is a Major Regulator of Phenylpropanoid Availability and Biological Activity in Plants.
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DOI：
10.3389/fpls.2016.00735
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发表时间：
2016
影响因子：
5.6
通讯作者：
Neutelings G
中科院分区：
文献类型：
--
作者：
Le Roy J;Huss B;Creach A;Hawkins S;Neutelings G
植物中的苯丙烷途径负责合成大量的苯丙氨酸和酪氨酸衍生的次生代谢产物。类黄酮和木质素都是在这种非常多样化的代谢途径的末端合成的，还有许多中间分子，其精确的生物学功能在很大程度上仍然未知。这些分子的多样性可以在UDP-糖基转移酶（UGT）的作用下进一步增加，导致糖基化羟基肉桂酸酯和相关醛、醇和酯的产生。糖基化可以改变苯丙素类化合物的溶解度、稳定性和潜在毒性，以及影响区室化和生物活性。因此，（去）-糖基化代表了苯丙素类体内平衡中极其重要的调节点。在这篇文章中，我们回顾了最近的知识参与调节苯丙素糖基化状态和可用性在不同的亚细胞室的酶。我们还研究了潜在的联系，单纤维素糖基化和木质化探索木质素生物合成基因和酚（去）糖基化基因的共表达。在与其特定化学性质相关的不同生物学作用中，苯丙素类化合物通常与植物的胁迫管理策略相关，这些策略也受糖基化调节。例如，UGT可以在微生物感染期间影响植物的抗性，并参与与环境变化相关的机制。本文还讨论了黄酮类化合物糖基化对花、叶、种子和果实颜色的影响。总之，本文强调的事实是，糖基化和去糖基化是强大的机制，允许植物调节苯丙素定位，可用性和生物活性。
The phenylpropanoid pathway in plants is responsible for the biosynthesis of a huge amount of secondary metabolites derived from phenylalanine and tyrosine. Both flavonoids and lignins are synthesized at the end of this very diverse metabolic pathway, as well as many intermediate molecules whose precise biological functions remain largely unknown. The diversity of these molecules can be further increased under the action of UDP-glycosyltransferases (UGTs) leading to the production of glycosylated hydroxycinnamates and related aldehydes, alcohols and esters. Glycosylation can change phenylpropanoid solubility, stability and toxic potential, as well as influencing compartmentalization and biological activity. (De)-glycosylation therefore represents an extremely important regulation point in phenylpropanoid homeostasis. In this article we review recent knowledge on the enzymes involved in regulating phenylpropanoid glycosylation status and availability in different subcellular compartments. We also examine the potential link between monolignol glycosylation and lignification by exploring co-expression of lignin biosynthesis genes and phenolic (de)glycosylation genes. Of the different biological roles linked with their particular chemical properties, phenylpropanoids are often correlated with the plant's stress management strategies that are also regulated by glycosylation. UGTs can for instance influence the resistance of plants during infection by microorganisms and be involved in the mechanisms related to environmental changes. The impact of flavonoid glycosylation on the color of flowers, leaves, seeds and fruits will also be discussed. Altogether this paper underlies the fact that glycosylation and deglycosylation are powerful mechanisms allowing plants to regulate phenylpropanoid localisation, availability and biological activity.