Efficacy of a combination of praziquantel and artesunate in the treatment of urinary schistosomiasis in Nigeria
Efficacy of a combination of praziquantel and artesunate in the treatment of urinary schistosomiasis in Nigeria
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DOI：
10.1016/j.trstmh.2008.08.002
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发表时间：
2009-01-01
影响因子：
2.2
通讯作者：
Inyang-Etoh, E. C.
中科院分区：
文献类型：
--
作者：
Inyang-Etoh, P. C.;Ejezie, G. C.;Inyang-Etoh, E. C.
对尼日利亚Adim社区随机抽取的312名4~20岁学龄儿童进行了吡喹酮和青蒿琥酯联合治疗尿路血吸虫病的疗效评估。在初步筛查中，在850名筛查对象中，有327人(38.5%)被确认感染。报告接受治疗的感染者随后被分成六个治疗组，每组52人；每组44人完成治疗方案并提交尿液进行治疗后评估。吡喹酮。青蒿琥酯分别按40 mg/kg和4 mg/kg体重灌胃。在用药后72小时评估药物反应的不良反应，并对所有感觉到的疾病发作进行治疗。在最后一次服药后56天对发病率指标进行评估。所有治疗方案耐受性良好。吡喹酮联合安慰剂组治愈率为72.7%，青蒿琥酯联合安慰剂组治愈率为70.5%，青蒿琥酯联合吡喹酮组治愈率最高(88.6%)。三种药物方案治疗后血尿和蛋白尿均明显减少。本研究证实吡喹酮联合青蒿琥酯治疗尿路血吸虫病安全有效。(C)2008年皇家热带医学和卫生学会。爱思唯尔有限公司出版。保留所有权利。
The combined effects of praziquantel and artesunate in the treatment of urinary schistosomiasis were assessed among 312 randomly selected schoolchildren aged 4-20 years in Adim community, Nigeria. In the preliminary screening, infection was confirmed in 327 (38.5%) of the 850 subjects screened. Infected subjects who reported for treatment were then divided into six treatment groups of 52 subjects each; 44 subjects in each group completed their treatment regimens and submitted their urine for post-treatment assessment. Praziquantel. and artesunate were administered orally at 40 mg/kg and 4 mg/kg body weight, respectively. Adverse effects due to drug reactions were assessed 72 h after medication and all perceived episodes of illness were treated. Morbidity indicators were assessed 56 days after the final dose of the drug regimens. All treatment regimens were well tolerated. The cure rates were 72.7% in the praziquantel plus placebo-treated group and 70.5% in the artesunate plus placebo group, white the artesunate plus praziquantel group had the highest cure rate (88.6%). Haematuria and proteinuria were extensively reduced after treatment with the three drug regimens. This study confirmed that the treatment of urinary schistosomiasis with the combination of praziquantel and artesunate is safe and more effective than treatment with either drug alone. (c) 2008 Royal Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd. All rights reserved.