PATERNAL ALCOHOL EXPOSURE AFFECTS OFFSPRING BEHAVIOR BUT NOT BODY OR ORGAN WEIGHTS IN MICE
PATERNAL ALCOHOL EXPOSURE AFFECTS OFFSPRING BEHAVIOR BUT NOT BODY OR ORGAN WEIGHTS IN MICE
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DOI：
10.1111/j.1530-0277.1988.tb00205.x
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发表时间：
1988-06-01
期刊：
影响因子：
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通讯作者：
LEE, JA
中科院分区：
文献类型：
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作者：
ABEL, EL;LEE, JA
雄性小鼠食用含有20%、10%或0%乙醇衍生卡路里（EDC）的液体酒精饮食56-61天。喂食10%和0%EDC饲料的动物与20%EDC动物成对喂食。纳入了未给药的自由采食组，以评估配对喂养的影响。给药后，雄性与未给药雌性交配。窝仔数、出生体重、21或55日龄时的体重和除胸腺外的器官重量不受父亲酒精摄入的影响。有一个剂量相关的减少活动在20日龄和24日龄的活动室和剂量相关的减少血清睾酮水平在55日龄的雄性后代由饮酒的男性。由食用20%EDC饮食的雄性繁殖的后代也需要更少的试验来学习被动回避任务，并且在T迷宫中有更长的潜伏期来达到选择点。
Male mice consumed liquid alcohol diets containing 20, 10, or 0% ethanol-derived calories (EDC) for 56-61 days. Animals fed the 10 and 0% EDC diets were pair-fed to 20% EDC animals. A nontreated ad libitum group was included to assess the effects of pair-feeding. After treatment, males were bred to nontreated females. Litter size, birthweight, bodyweight at 21 or 55 days of age, and organ weights except for thymus were not affected by paternal alcohol ingestion. There was a dose-related decrease in activity at 20 and 24 days of age in an activity chamber and a dose-related decrease in serum testosterone levels at 55 days of age in male offspring sired by alcohol-consuming males. Offspring sired by males consuming the 20% EDC diet also required fewer trials to learn a passive avoidance task and had longer latencies to reach the choice point in a T maze.