Depot-Dependent Impact of Time-Restricted Feeding on Adipose Tissue Metabolism in High Fat Diet-Induced Obese Male Mice.
Depot-Dependent Impact of Time-Restricted Feeding on Adipose Tissue Metabolism in High Fat Diet-Induced Obese Male Mice.
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DOI：
10.3390/nu15010238
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发表时间：
2023-01-03
期刊：
影响因子：
5.9
通讯作者：
Chen X
中科院分区：
文献类型：
--
作者：
Bushman T;Lin TY;Chen X
限时喂养（TRF）是减肥和代谢健康的有效策略。TRF对代谢的影响是复杂的，可能作用于多个组织内的各种途径。脂肪组织在糖和脂质代谢的系统内稳态中起关键作用。脂肪组织失调与肥胖症的代谢紊乱有因果关系。然而，TRF如何影响肥胖症中不同脂肪组织库内的代谢途径如脂解、脂肪生成和产热在很大程度上是未知的。为了确定这一点，我们对雄性小鼠进行了为期10周的TRF方案，之前接受了长期高脂肪饮食（HFD），并使小鼠每天接受HFD的TRF 10小时或随意进食。TRF方案显示体重增加减少。TRF恢复了HFD诱导的脂肪形成损伤，并增加了白色脂肪组织中的脂质储存。TRF还显示了在脂质代谢中的贮库依赖性作用，并恢复了在附睾脂肪组织中被HFD损害的脂肪生成和脂解的ATP消耗无效循环，但不是腹股沟脂肪贮库。我们证明，TRF可能是一个有益的选择，作为一种饮食和生活方式的干预，在降低体重和改善脂肪组织代谢。
Time-restricted feeding (TRF) is known to be an effective strategy for weight loss and metabolic health. TRF’s effect on metabolism is complex and likely acts on various pathways within multiple tissues. Adipose tissue plays a key role in systemic homeostasis of glucose and lipid metabolism. Adipose tissue dysregulation has been causally associated with metabolic disorders in obesity. However, it is largely unknown how TRF impacts metabolic pathways such as lipolysis, lipogenesis, and thermogenesis within different in adipose tissue depots in obesity. To determine this, we conducted a 10-week TRF regimen in male mice, previously on a long-term high fat diet (HFD) and subjected the mice to TRF of a HFD for 10 h per day or ad libitum. The TRF regimen showed reduction in weight gain. TRF restored HFD-induced impairment of adipogenesis and increased lipid storage in white adipose tissues. TRF also showed a depot-dependent effect in lipid metabolism and restored ATP-consuming futile cycle of lipogenesis and lipolysis that is impaired by HFD within epididymal adipose tissue, but not inguinal fat depot. We demonstrate that TRF may be a beneficial option as a dietary and lifestyle intervention in lowering bodyweight and improving adipose tissue metabolism.