Acute changes in dietary omega-3 fatty acid intake lowers soluble interleukin-6 receptor in healthy adult normal weight and overweight males.
Acute changes in dietary omega-3 fatty acid intake lowers soluble interleukin-6 receptor in healthy adult normal weight and overweight males.
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膳食 omega-3 脂肪酸摄入量的急剧变化会降低健康成年正常体重和超重男性的可溶性白细胞介素 6 受体。
DOI：
10.1016/j.cyto.2004.02.010
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发表时间：
2004
期刊：
影响因子：
3.8
通讯作者：
M. Hickey
中科院分区：
文献类型：
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作者：
T. Nelson;M. Hickey
目的：确定短期等热量α-亚麻酸（ALA，18：3 n3）交换亚油酸（LA，18：2n 6）对健康正常体重和超重/肥胖成年男性空腹可溶性白细胞介素-6受体（sIL-6 R）和可溶性肿瘤坏死因子-α受体1和2（sTNFR 1和sTNFR 2）水平的影响。在两种饮食处理中，在第5天早晨获得空腹（10小时）血液样品以测量sTNFR 1、sTNFR 2、受试者正常体重（BMI <25 kg / m2）和7例超重在正常体重和超重/肥胖的健康男性中，在高ALA等热量（ISO）饮食四天后，空腹sIL 6 R从对照（C）饮食显著降低。肥胖者（正常体重：C =34.89±3.17 ng / ml，ISO =30.91±2.24 ng / ml，p<0.05;超重/肥胖：C =38.19±3.92 ng / ml，ISO =33.57±2.47 ng / ml，p<0.05）。饮食干预对空腹sTNFR 1和sTNFR 2无显著影响。结论：在超重/肥胖和正常体重的受试者中，等热量的ALA与LA的交换可使空腹sIL 6 R浓度降低约11%。数据还表明，长期接触类似的饮食可能有可能减少炎症负担，从而降低心血管疾病和糖尿病的风险。
OBJECTIVETo determine the effect of a short-term isocaloric exchange of alpha-linolenic acid (ALA, 18:3n3) for linoleic acid (LA, 18:2n6) on fasting levels of soluble interleukin-6 receptor (sIL6R), and soluble tumor necrosis factor-alpha receptors 1 and 2 (sTNFR1 and sTNFR2) in healthy normal weight and overweight/obese adult males.DESIGNFour-day clinical intervention study with 0.5% or 5% of total energy from ALA. Fasting (10h) blood samples were obtained on the morning of day 5 in both diet treatments to measure sTNFR1, sTNFR2, and sIL6R.SUBJECTSNine normal weight (BMI <25 kg / m2) and seven overweight (BMI ≥25 kg / m2) healthy males.RESULTSFasting sIL6R decreased significantly from the control (C) diet following four days on the high ALA isocaloric (ISO) diet in normal weight and overweight/obese subjects (normal weight: C =34.89±3.17 ng / ml , ISO =30.91±2.24 ng / ml , p<0.05; overweight/obese: C =38.19±3.92 ng / ml , ISO =33.57±2.47 ng / ml , p<0.05). The dietary intervention did not have a significant effect on fasting sTNFR1 or sTNFR2.CONCLUSIONSThe results suggest that an isocaloric exchange of ALA for LA can reduce fasting sIL6R concentration by ∼11% after a four-day dietary intervention in both overweight/obese and normal weight subjects. The data also suggest that longer exposure to a similar diet may have the potential to reduce inflammatory burden and thus lower the risk of both cardiovascular disease as well as diabetes.
欧米伽 3 脂肪酸对心血管的影响。
影响因子：
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作者：
Weber,PC;Leaf,A
通讯作者：
Leaf,A
影响因子：
158.5
作者：
Ridker, PM;Rifai, N;Cook, NR
通讯作者：
Cook, NR