Non-ionic PEG-Oligoglycerol Dendron Conjugated Nano-carriers for Transdermal Delivery.
Non-ionic PEG-Oligoglycerol Dendron Conjugated Nano-carriers for Transdermal Delivery.
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DOI：
10.1016/j.ijpharm.2020.119212
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发表时间：
2020-03
影响因子：
5.8
通讯作者：
Rashmi;F. Zabihi;A. Singh;K. Achazi;B. Schade;S. Hedtrich;R. Haag;Sunil K. Sharma
中科院分区：
文献类型：
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作者：
Rashmi;F. Zabihi;A. Singh;K. Achazi;B. Schade;S. Hedtrich;R. Haag;Sunil K. Sharma
以聚乙二醇（PEG）和低聚甘油树枝状分子为亲水单元，以烷氧基芳基为疏水单元，合成了一类新型非离子两亲分子。发现所得两亲物在水介质中聚集。它们的聚集行为进行了研究，使用动态光散射（DLS），荧光光谱，和低温电子显微镜（cryo-TEM）。这些聚集体在水性介质中的内部疏水核能够包封亲脂性客体分子。使用尼罗红作为疏水性染料以及姜黄素和地塞米松作为疏水性药物候选物来研究包封行为。此外，对于生物学评价，使用不同的癌细胞系研究了细胞毒性和细胞摄取。进一步研究了合成的两亲物的生物医学应用，用于使用包封在纳米载体中的尼罗红在离体人皮肤上的皮肤药物递送。药物/染料包封的两亲物的释放曲线进行了研究，在物理化学条件下，在固定化脂肪酶诺维信435的存在下。
A new class of non-ionic amphiphiles have been synthesised using a combination of polyethylene glycol (PEG) and oligoglycerol dendrons as hydrophilic units and an alkoxy aryl moiety as hydrophobic unit. The resulting amphiphiles were found to aggregate in aqueous medium. Their aggregation behaviour was studied using dynamic light scattering (DLS), fluorescence spectroscopy, and cryogenic electron microscopy (cryo-TEM). The inner hydrophobic core of these aggregates in aqueous medium is capable of encapsulating lipophilic guest molecules. The encapsulation behaviour was studied using Nile red as a hydrophobic dye as well as Curcumin and Dexamethasone as hydrophobic drug candidates. Furthermore, for biological evaluation, cytotoxicity and cellular uptake was studied using different cancer cell lines. The biomedical application of synthesised amphiphiles was further investigated for dermal drug delivery on excised human skin using Nile red encapsulated in the nanocarrier. The release profile of drug/dye encapsulated amphiphiles was studied under physiochemical conditions in the presence of immobilized lipase Novozym 435.