Trends in cervical cancer incidence in sub-Saharan Africa
Trends in cervical cancer incidence in sub-Saharan Africa
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DOI：
10.1038/s41416-020-0831-9
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发表时间：
2020-04-27
影响因子：
8.8
通讯作者：
Parkin, Donald Maxwell
中科院分区：
文献类型：
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作者：
Jedy-Agba, Elima;Joko, Walburga Yvonne;Parkin, Donald Maxwell
背景宫颈癌是撒哈拉以南非洲(SSA)妇女的第二大常见癌症，也是女性癌症死亡的主要原因。方法在8个SSA国家(冈比亚、肯尼亚、马拉维、毛里求斯、塞舌尔、南非、乌干达和津巴布韦)的10个以人口为基础的癌症登记中，对宫颈癌的发病率趋势进行了为期10-25年的调查。共有21,990例宫颈癌病例被纳入分析。结果在研究的部分或全部期间，除毛里求斯外，所有登记处的发病率都有所上升，年降幅为2.5%。东开普省和布兰太尔(马拉维)的登记数随着时间的推移显示出显著增长，其中布兰太尔的登记最快(每年7.9%)。在坎帕拉(乌干达)，在2006年之前出现了显著的增长(2.2%)，随后出现了不明显的下降。在埃尔多雷特，下降(1998-2002年)之后是2002年至2016年的显著增长(9.5%)。结论总体上，SSA地区宫颈癌发病率呈上升趋势。目前在南非为减轻宫颈癌负担而进行的高级别宣传需要转化为对预防的支持(人乳头瘤病毒疫苗接种和全人口筛查)，并通过基于人口的登记对结果进行仔细监测。
Background Cervical cancer is the second most common cancer and the leading cause of cancer death in women in sub-Saharan Africa (SSA). Methods Trends in the incidence of cervical cancer are examined for a period of 10-25 years in 10 population-based cancer registries across eight SSA countries (Gambia, Kenya, Malawi, Mauritius, Seychelles, South Africa, Uganda and Zimbabwe). A total of 21,990 cases of cervical cancer were included in the analyses. Results Incidence rates had increased in all registries for some or all of the periods studied, except for Mauritius with a constant annual 2.5% decline. Eastern Cape and Blantyre (Malawi) registries showed significant increases over time, with the most rapid being in Blantyre (7.9% annually). In Kampala (Uganda), a significant increase was noted (2.2%) until 2006, followed by a non-significant decline. In Eldoret, a decrease (1998-2002) was followed by a significant increase (9.5%) from 2002 to 2016. Conclusion Overall, cervical cancer incidence has been increasing in SSA. The current high-level advocacy to reduce the burden of cervical cancer in SSA needs to be translated into support for prevention (vaccination against human papillomavirus and population-wide screening), with careful monitoring of results through population-based registries.