A nanotube based electron microbeam cellular irradiator for radiobiology research
A nanotube based electron microbeam cellular irradiator for radiobiology research
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DOI：
10.1063/1.3043417
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发表时间：
2008-12-01
影响因子：
1.6
通讯作者：
Chang, Sha
中科院分区：
文献类型：
--
作者：
Bordelon, David E.;Zhang, Jian;Chang, Sha
A prototype cellular irradiator utilizing a carbon nanotube (CNT) based field emission electron source has been developed for microscopic image-guided cellular region irradiation. The CNT cellular irradiation system has shown great potential to be a high temporal and spatial resolution research tool to enable researchers to gain a better understanding of the intricate cellular and intercellular microprocesses occurring following radiation deposition, which is essential to improving radiotherapy cancer treatment outcomes. In this paper, initial results of the system development are reported. The relationship between field emission current, the dose rate, and the dose distribution has been investigated. A beam size of 23 mu m has been achieved with variable dose rates of 1-100 Gy/s, and the system dosimetry has been measured using a radiochromic film. Cell irradiation has been demonstrated by the visualization of H2AX phosphorylation at DNA double-strand break sites following irradiation in a rat fibroblast cell monolayer. The prototype single beam cellular irradiator is a preliminary step to a multipixel cell irradiator that is under development.
