Genetics of complex airway disease.
Genetics of complex airway disease.
复制标题
DOI：
10.1513/pats.201101-003ms
复制
发表时间：
2011-05-01
期刊：
影响因子：
--
通讯作者：
Moffatt, Miriam F
中科院分区：
文献类型：
--
作者：
Cookson, William O C;Moffatt, Miriam F
在过去的3年里，已经发现了对各种常见复杂疾病的高度显著的遗传影响，包括哮喘和慢性阻塞性肺病的气道障碍。似乎只有一部分遗传介导的对复杂疾病的易感性已被确定，还有很多有待发现。这篇综述简要描述了哮喘全基因组关联研究的结果，并概述了正在进行的与慢性阻塞性肺疾病相关的平行且越来越大规模的研究。未来的影响讨论了技术进步，允许越来越大规模的基因表达研究，下一代测序和全基因组检测的表观遗传效应。使用基因技术来检查气道微生物群相互作用与粘膜在健康和疾病被描述。
The past 3 years have seen highly significant genetic effects identified for a wide variety of common complex diseases, including the airway disorders of asthma and chronic obstructive pulmonary disease. It appears that only a portion of the genetically mediated susceptibility to complex diseases has been identified, and there is much left to be discovered. This review briefly describes the results of the genome-wide association studies of asthma and gives an overview of the parallel and increasingly large-scale studies that are taking place with chronic obstructive pulmonary disease. The future impact is discussed of technological advances that allow increasingly large-scale gene expression studies, next-generation sequencing, and genome-wide testing for epigenetic effects. The use of genetic technology to examine the airway microbiota that interact with the mucosa in health and disease is described.