Integrins as receptor targets for neurological disorders.
Integrins as receptor targets for neurological disorders.
复制标题
DOI：
10.1016/j.pharmthera.2011.12.008
复制
发表时间：
2012-04
影响因子：
13.5
通讯作者：
Reddy, Doodipala Samba
中科院分区：
文献类型：
--
作者：
Wu, Xin;Reddy, Doodipala Samba
本综述重点关注整合素的神经生物学、整合素在神经可塑性和神经系统疾病中的病理生理学作用，以及整合素作为潜在药物靶点和可能的递送途径的治疗意义。神经可塑性是许多神经系统疾病（如癫痫、创伤和创伤性脑损伤）的核心现象。在许多脑部疾病的过程中，除了细胞内区室的变化外，细胞外基质（ECM）等非细胞区室的变化也被认为是形成和重组神经连接的重要过程。整合素是介导细胞-ECM 和细胞-细胞粘附事件的异二聚体跨膜受体。尽管神经可塑性的机制尚不清楚，但有人认为整合素具有可塑性，包括通过与 ECM 蛋白相互作用进行聚类、调节离子通道、细胞内 Ca2+ 和蛋白激酶信号传导以及细胞骨架丝的重组。作为细胞表面受体，整合素是许多脑部疾病（例如癫痫）病理生理学的核心，也是开发神经系统疾病新药的潜在靶点。
This review focuses on the neurobiology of integrins, pathophysiological roles of integrins in neuroplasticity and nervous system disorders, and therapeutic implications of integrins as potential drug targets and possible delivery pathways. Neuroplasticity is a central phenomenon in many neurological conditions such as seizures, trauma, and traumatic brain injury. During the course of many brain diseases, in addition to intracellular compartment changes, alterations in non-cell compartments such as extracellular matrix (ECM) are recognized as an essential process in forming and reorganizing neural connections. Integrins are heterodimeric transmembrane receptors that mediate cell–ECM and cell–cell adhesion events. Although the mechanisms of neuroplasticity remain unclear, it has been suggested that integrins undergo plasticity including clustering through interactions with ECM proteins, modulating ion channels, intracellular Ca2+ and protein kinases signaling, and reorganization of cytoskeletal filaments. As cell surface receptors, integrins are central to the pathophysiology of many brain diseases, such as epilepsy, and are potential targets for the development of new drugs for neurological disorders.
登录
查看更多内容
影响因子：
3.5
作者：
Bozzo, C;Lombardi, G;Canonico, PL
通讯作者：
Canonico, PL
影响因子：
2
作者：
Chang, HP;Lindberg, FP;Lee, EHY
通讯作者：
Lee, EHY
影响因子：
5.3
作者：
Bukalo, Olena;Schachner, Melitta;Dityatev, Alexander
通讯作者：
Dityatev, Alexander
影响因子：
3.3
作者：
Chun, D;Gall, CM;Lynch, G
通讯作者：
Lynch, G
影响因子：
64.8
作者：
Chavis, P;Westbrook, G
通讯作者：
Westbrook, G