Long Noncoding RNA: A Novel Insight into the Pathogenesis of Acute Lung Injury.
Long Noncoding RNA: A Novel Insight into the Pathogenesis of Acute Lung Injury.
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DOI：
10.3390/jcm12020604
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发表时间：
2023-01-11
影响因子：
3.9
通讯作者：
中科院分区：
文献类型：
--
作者：
急性肺损伤（ALI）及其严重形式，急性呼吸窘迫综合征（ARDS），代表肺泡上皮细胞丧失其功能的肺部炎症的急性阶段。ALI对人群具有破坏性影响，因为它不仅具有高发病率，而且具有高发病率和死亡率。由于多种因素的参与，ALI的发病机制十分复杂，至今尚未完全阐明。长链非编码RNA（lncRNA）是一组长度超过200个核苷酸的非蛋白质编码转录物。越来越多的证据表明lncRNA在ALI的发病机制中起决定性作用。LncRNA可以促进或阻碍肺中各种细胞类型中的ALI的发展。从机制上讲，目前的研究已经发现lncRNA通过调节小RNA（例如，microRNA）或下游蛋白质。lncRNA不仅有可能揭示ALI的发病机制，而且可以作为诊断和治疗ALI的靶点。
Acute lung injury (ALI) and its severe form, acute respiratory distress syndrome (ARDS), represent an acute stage of lung inflammation where the alveolar epithelium loses its functionality. ALI has a devastating impact on the population as it not only has a high rate of incidence, but also has high rates of morbidity and mortality. Due to the involvement of multiple factors, the pathogenesis of ALI is complex and is not fully understood yet. Long noncoding RNAs (lncRNAs) are a group of non-protein-coding transcripts longer than 200 nucleotides. Growing evidence has shown that lncRNAs have a decisive role in the pathogenesis of ALI. LncRNAs can either promote or hinder the development of ALI in various cell types in the lungs. Mechanistically, current studies have found that lncRNAs play crucial roles in the pathogenesis of ALI via the regulation of small RNAs (e.g., microRNAs) or downstream proteins. Undoubtedly, lncRNAs not only have the potential to reveal the underlying mechanisms of ALI pathogenesis but also serve as diagnostic and therapeutic targets for the therapy of ALI.
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