Animal Models of Obsessive‐Compulsive Disorder
Animal Models of Obsessive‐Compulsive Disorder
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强迫症动物模型
DOI：
10.1002/0471142301.ns0930s45
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发表时间：
2008
影响因子：
--
通讯作者：
J. Witkin
中科院分区：
文献类型：
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作者：
J. Witkin
强迫症（OCD）的发病率很高，而用于治疗强迫症的药物疗效有限且存在副作用问题。缺乏预测性体内模型在一定程度上阻碍了强迫症改良药物的发现。本单元简要概述了可能具有此类预测效用的两种方法。埋大理石和撕碎巢是小鼠自发发生的两种高频率、重复性行为。这些急性体内测定相对容易进行。选择性血清素摄取抑制剂可减少这些行为，而不会产生运动副作用（通过在旋转杆上行走的行为进行评估）。相比之下，其他一些药物（例如苯二氮卓类抗焦虑药）仅在损害运动的剂量下才会影响大理石埋藏和燕窝粉碎。因此，本方法可能为发现针对强迫症症状的新型化学治疗解决方案提供一条体内信息。电流。协议。神经科学。 45：9.30.1‐9.30.9。 © 2008 John Wiley & Sons, Inc. 版权所有
Obsessive‐compulsive disorder (OCD) occurs with high prevalence, and the drugs used to treat OCD are limited in efficacy and have side‐effect issues. The discovery of improved medicines for OCD has been hampered in part by the lack of predictive in vivo models. This unit provides a brief overview of two methods that might have such predictive utility. Marble burying and nestlet shredding are two behaviors that occur spontaneously with high frequency and repetitiveness in mice. These acute in vivo assays are relatively easy to conduct. Selective serotonin uptake inhibitors decrease these behaviors without producing motor side effects, as assessed by the behavior of walking on a rotating rod. In contrast, some other drugs (e.g., benzodiazepine anxiolytics) only affect marble burying and nestlet shredding at motor‐impairing doses. The present methods might therefore provide one piece of in vivo information for the discovery of novel chemical treatment solutions for the symptoms of OCD. Curr. Protoc. Neurosci. 45:9.30.1‐9.30.9. © 2008 by John Wiley & Sons, Inc.