The prognostic role of mTOR and p-mTOR for survival in non-small cell lung cancer: a systematic review and meta-analysis.
The prognostic role of mTOR and p-mTOR for survival in non-small cell lung cancer: a systematic review and meta-analysis.
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mTOR 和 p-mTOR 对非小细胞肺癌生存的预后作用：系统评价和荟萃分析。
DOI：
10.1371/journal.pone.0116771
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Li WM
中科院分区：
文献类型：
--
作者：
Li L;Liu D;Qiu ZX;Zhao S;Zhang L;Li WM
哺乳动物雷帕霉素靶点 (mTOR) 和磷酸化 mTOR (p-mTOR) 是非小细胞肺癌 (NSCLC) 的潜在预后标志物和治疗靶点。然而，mTOR/p-mTOR表达与NSCLC患者预后之间的关系仍存在争议。因此，对评估 mTOR/p-mTOR 表达对 NSCLC 预后作用的现有研究进行了荟萃分析。通过Pubmed、Embase、Medline以及CNKI（中国国家知识基础设施）进行了系统的文献检索。纳入的研究报告了 mTOR/p-mTOR 表达与 NSCLC 患者生存之间关联的风险比 (HR) 和 95% CI。使用随机效应模型来汇集 HR。本荟萃分析纳入了 10 项符合条件的研究，其中 4 项关于 m-TOR，7 项关于 p-mTOR。对于 mTOR，单变量分析的总生存 (OS) 汇总 HR 为 1.00（95% CI 0.5 至 1.99），多变量分析为 1.22（95% CI 0.53 至 2.82）。对于 p-mTOR，单变量分析的汇总 HR 为 1.39（95% CI 0.97 至 1.98），多变量分析的汇总 HR 为 1.42（95% CI 0.56 至 3.60）。结果表明，mTOR/p-mTOR表达与NSCLC患者预后之间没有发现统计学上显着的关联。
The mammalian target of rapamycin (mTOR) and phosphorylated mTOR (p-mTOR) are potential prognostic markers and therapeutic targets for non-small cell lung cancer (NSCLC). However, the association between mTOR/p-mTOR expression and NSCLC patients’ prognosis remains controversial. Thus, a meta-analysis of existing studies evaluating the prognostic role of mTOR/p-mTOR expression for NSCLC was conducted. A systemically literature search was performed via Pubmed, Embase, Medline as well as CNKI (China National Knowledge Infrastructure). Studies were included that reported the hazard ratio (HR) and 95%CI for the association between mTOR/p-mTOR expression and NSCLC patients’ survival. Random-effects model was used to pool HRs. Ten eligible studies were included in this meta-analysis, with 4 about m-TOR and 7 about p-mTOR. For mTOR, the pooled HR of overall survival (OS) was 1.00 (95%CI 0.5 to 1.99) by univariate analysis and 1.22 (95%CI 0.53 to 2.82) by multivariate analysis. For p-mTOR, the pooled HR was 1.39 (95%CI 0.97 to 1.98) by univariate analysis and 1.42 (95%CI 0.56 to 3.60) by multivariate analysis. The results indicated that no statistically significant association was found between mTOR/p-mTOR expression and NSCLC patients’ prognosis.
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