AUTOREGULATION OF CORONARY BLOOD FLOW - EFFECT OF INTERARTERIAL PRESSURE GRADIENTS
AUTOREGULATION OF CORONARY BLOOD FLOW - EFFECT OF INTERARTERIAL PRESSURE GRADIENTS
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DOI：
10.1161/01.res.15.2.103
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发表时间：
1964-01-01
影响因子：
20.1
通讯作者：
ECKSTEIN, RW
中科院分区：
文献类型：
--
作者：
DRISCOL, TE;MOIR, TW;ECKSTEIN, RW
在开胸犬中，插管左回旋动脉的第一个主要分支，并研究冠脉灌注压突然变化后的流入模式。周围血管的压力是通过独立调节左冠状动脉连接处的压力来控制的，从而控制冠状动脉间侧支流入和流出由分支动脉供应的肌肉。冠状动脉血流反应几乎不受主动脉之间较大的压力梯度(80毫米汞柱)的影响。在所有实验中都观察到了流量的自动调节，其定义是流量恢复到控制值，尽管在60%的实验中，稳态冠脉阻力随着灌流压力的增加而降低。主动脉压力的突然升高并不会导致流量的即刻增加，而不是仅由可比的灌流压力增加所产生的流量增加。在正常心脏中，冠状动脉间侧支循环不会显著地夸大或最小化冠状动脉血流的自动调节。主动脉压力改变后冠状动脉血管阻力无反射性改变。由于血管阻力值不一定反映自动调节的存在或不存在，因此有必要检查灌流压力突然变化后的整个血流模式，以证明冠脉血流量的重要决定因素。
In open chest dogs the first major branch of the left circumflex artery was cannulated and inflow patterns were studied following abrupt changes in coronary perfusion pressure. Pressure in surrounding vessels was controlled by regulating independently pressure in the connion left coronary artery, thus controlling intercoronary collateral flow into and from the muscle supplied by the branch artery. Coronary flow responses were little affected by sizeable pressure gradients (80 mm Hg) between major arteries. Autoregulation of flow, defined by a return of flow toward control value was observed in all experiments though in 60% of the experiments steady state coronary vascular-resistance decreased as perfusion pressure was raised. Sudden increases in aortic pressure did not result in immediate flow increases greater than those increases produced by comparable increases in perfusion pressure alone. Autoregulation of coronary flow is not exaggerated or minimized significantly by intercoronary collateral flow in a normal heart. Reflex alterations in coronary vascular resistance after changes in aortic pressure were not present. Since vascular resistance values do not necessarily reflect the presence or absence of autoregulation, it is necessary to examine the entire flow pattern following sudden changes in perfusion pressure in order to demonstrate the important determinants of coronary blood flow.