Coagulation/fibrinolysis abnormality and vascular endothelial damage in the pathogenesis of thrombocytopenic multiple organ failure
Coagulation/fibrinolysis abnormality and vascular endothelial damage in the pathogenesis of thrombocytopenic multiple organ failure
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DOI：
10.1097/00003246-200210000-00011
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发表时间：
2002-10-01
影响因子：
8.8
通讯作者：
Matsuda, K
中科院分区：
文献类型：
--
作者：
Ueno, H;Hirasawa, H;Matsuda, K
目的：直到最近，人们的注意力一直集中在弥散性血管内凝血作为多器官衰竭（MOF）的原因。另一方面，现在已经清楚体液介质在MOF的发病机制中起重要作用。因此，我们在血小板减少性MOF患者中进行了本研究，以研究各种体液介质与MOF发病机制中这些体液介质引发的血管内皮损伤之间的关系。设计：回顾性临床研究。环境：一所大学医院的加护病房。患者：该研究包括18例进展为脓毒性MOF的血小板减少患者（MOF组）和20例未进展为MOF的患者（非MOF组）。MOF组和非MOF组均出现感染和血小板计数
Objective: Until recently, attention has been directed to disseminated intravascular coagulation as a cause of multiple organ failure (MOF). On the other hand, it has now become clear that humoral mediators play important roles in the pathogenesis of MOF. Therefore, we performed the present study in patients with thrombocytopenic MOF to investigate the relationship between various humoral mediators and vascular endothelial damage reported to be triggered by such humoral mediators in the pathogenesis of MOF.Design: A retrospective clinical study.Setting: Intensive care unit of a university hospital.Patients: The study included 18 thrombocytopenic patients whose conditions progressed to septic MOF (MOF group) and 20 others who did not progress to MOF (non-MOF group). The MOF group and non-MOF group were also presented with infection and with platelet counts of