Transcriptional memory at the nuclear periphery
Transcriptional memory at the nuclear periphery
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DOI：
10.1016/j.ceb.2009.01.007
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发表时间：
2009-02-01
影响因子：
7.5
通讯作者：
Brickner, Jason H.
中科院分区：
文献类型：
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作者：
Brickner, Jason H.
许多可诱导的酵母基因在转录激活后靶向核外围。然而，当再次被抑制时，INO 1和GAL 1基因在多代中仍保持在核外围。保留在核周边代表了一种新型的转录记忆;周边本地化，最近抑制状态的GAL 1被激活的速度比核质本地化的长期抑制状态的GAL 1。这种快速再活化涉及在核周边的定位、SWI/SNF染色质重塑复合物、组蛋白变体H2A.Z和Gall蛋白本身。在这里，我回顾了我们已经了解到的酵母中这种类型的转录记忆，还有什么有待解决，以及与理解这种表观遗传现象相关的挑战。
A number of inducible yeast genes are targeted to the nuclear periphery upon transcriptional activation. However, when repressed again, the INO1 and GAL1 genes remain at the nuclear periphery for multiple generations. Retention at the nuclear periphery represents a novel type of transcriptional memory; the peripherally localized, recently repressed state of GAL1 is activated more rapidly than the nucleoplasmically localized long-term repressed state of GAL1. This rapid reactivation involves localization at the nuclear periphery, the SWI/SNF chromatin remodeling complex, the histone variant H2A.Z and the Gall protein itself. Here, I review what we have learned about this type of transcriptional memory in yeast, what remains to be resolved and the challenges associated with understanding such epigenetic phenomena.