Effects of noise on the spike timing precision of retinal ganglion cells
Effects of noise on the spike timing precision of retinal ganglion cells
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DOI：
10.1152/jn.01106.2002
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发表时间：
2003-05-01
影响因子：
2.5
通讯作者：
Smith, RG
中科院分区：
文献类型：
--
作者：
van Rossum, MCW;O'Brien, BJ;Smith, RG
尖峰序列中的信息受尖峰时序的可变性限制。这种可变性是由包括突触和膜通道在内的几个来源的噪声引起的；但每个噪声源的危害有多大以及它们如何影响棘波序列编码尚不清楚。结合生理学和多室模型，我们研究了突触输入噪声和电压门控通道噪声对哺乳动物神经节细胞棘波序列可靠性的影响。对于紧张性刺激，峰间期的标准差随峰间期的增加而超早增加。当细胞被注入电流驱动时，电压门控通道噪声和背景突触噪声引起幅度相当的棘波间期的波动。在树突上启动的尖峰可能会引起额外的尖峰时间波动。对于瞬时刺激，突触噪声占主导地位，自发的背景活动强烈增加了峰时的波动，但缩短了第一个峰的潜伏期。
Information in a spike train is limited by variability in the spike timing. This variability is caused by noise from several sources including synapses and membrane channels; but how deleterious each noise source is and how they affect spike train coding is unknown. Combining physiology and a multicompartment model, we studied the effect of synaptic input noise and voltage-gated channel noise on spike train reliability for a mammalian ganglion cell. For tonic stimuli, the SD of the interspike intervals increased supralinearly with increasing interspike interval. When the cell was driven by current injection, voltage-gated channel noise and background synaptic noise caused fluctuations in the interspike interval of comparable amplitude. Spikes initiated on the dendrites could cause additional spike timing fluctuations. For transient stimuli, synaptic noise was dominant and spontaneous background activity strongly increased fluctuations in spike timing but decreased the latency of the first spike.