Wound repair: toward understanding and integration of single-cell and multicellular wound responses.
Wound repair: toward understanding and integration of single-cell and multicellular wound responses.
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DOI：
10.1146/annurev-cellbio-092910-154251
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发表时间：
2011
影响因子：
11.3
通讯作者：
Bement WM
中科院分区：
文献类型：
--
作者：
Sonnemann KJ;Bement WM
伤口愈合对医学和生物学的重要性早已显而易见，因此，伤口愈合多年来一直是深入研究的主题。然而，一些相对较新的发展增加了新的动力，伤口修复研究：模型系统的应用越来越多，越来越认识到单细胞具有强大的，复杂的，医学相关的伤口愈合反应，和新兴的认识，不同的模式的伤口修复承担一个不可思议的相似之处，其他基本的生物过程，如形态发生和胞质分裂。在这篇综述中，描述了这些进展中的每一项，并考虑了它们对伤口愈合研究的意义。此外，强调了单细胞和多细胞伤口愈合的重叠机制，并且认为它们比通常认识到的更相似。基于这一点和其他信息，提出了一个简单的模型来解释细胞质分裂，单细胞伤口修复，多细胞伤口修复和发育形态发生的进化关系。最后，提出了一系列重要但尚未得到解答的问题。
The importance of wound healing to medicine and biology has long been evident, and consequently, wound healing has been the subject of intense investigation for many years. However, several relatively recent developments have added new impetus to wound repair research: the increasing application of model systems; the growing recognition that single cells have a robust, complex, and medically relevant wound healing response; and the emerging recognition that different modes of wound repair bear an uncanny resemblance to other basic biological processes such as morphogenesis and cytokinesis. In this review, each of these developments is described, and their significance for wound healing research is considered. In addition, overlapping mechanisms of single-cell and multicellular wound healing are highlighted, and it is argued that they are more similar than is often recognized. Based on this and other information, a simple model to explain the evolutionary relationships of cytokinesis, single-cell wound repair, multicellular wound repair, and developmental morphogenesis is proposed. Finally, a series of important, but as yet unanswered, questions is posed.