Inflammation, proteases and cancer
Inflammation, proteases and cancer
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DOI：
10.1016/j.ejca.2006.01.004
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发表时间：
2006-04-01
影响因子：
8.4
通讯作者：
Coussens, LM
中科院分区：
文献类型：
--
作者：
van Kempen, LCL;de Visser, KE;Coussens, LM
肿瘤是由不断进化的肿瘤细胞、提供结构支持和隔离生物活性分子的基质蛋白以及细胞基质成分组成的复杂组织。肿瘤细胞、活化的宿主细胞和它们所处的动态微环境之间的相互作用使肿瘤生长和传播成为可能。很明显，在肿瘤发展过程中或周围观察到的早期和持续的炎症反应，通过提供与维持组织稳态有关的多种介质，如可溶性生长和生存因子、基质重塑酶、活性氧和其他生物活性分子，调节肿瘤发展的许多方面（基质重塑、血管生成、恶性潜能）。这篇综述强调了最近对慢性炎症与癌症发展相关的作用的见解，并研究了组织肿瘤编程过程中浸润白细胞激活的蛋白水解途径。(c) 2006 Elsevier Ltd.版权所有。
Tumours are complex tissues composed of ever-evolving neoplastic cells, matrix proteins that provide structural support and sequester biologically active molecules, and a cellular stromal component. Reciprocal interactions between neoplastic cells, activated host cells and the dynamic micro-environment in which they live enables tumour growth and dissemination. It has become evident that early and persistent inflammatory responses observed in or around developing neoplasms regulates many aspects of tumour development (matrix remodelling, angiogenesis, malignant potential) by providing diverse mediators implicated in maintaining tissue homeostasis, e.g., soluble growth and survival factors, matrix remodelling enzymes, reactive oxygen species and other bioactive molecules. This review highlights recent insights into the role of chronic inflammation associated with cancer development and examines proteolytic pathways activated by infiltrating leukocytes during neoplastic programming of tissues. (c) 2006 Elsevier Ltd. All rights reserved.