RELATIONS BETWEEN PANCREATIC ENZYME OUTPUTS AND MALABSORPTION IN SEVERE PANCREATIC INSUFFICIENCY
RELATIONS BETWEEN PANCREATIC ENZYME OUTPUTS AND MALABSORPTION IN SEVERE PANCREATIC INSUFFICIENCY
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DOI：
10.1056/nejm197304192881603
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发表时间：
1973-01-01
影响因子：
158.5
通讯作者：
SUMMERSKILL, WH
中科院分区：
文献类型：
--
作者：
DIMAGNO, EP;GO, VLW;SUMMERSKILL, WH
为探讨胰腺外分泌的功能储备能力，我们研究了17例慢性胰腺炎患者和33例健康人的脂肪酶和胰蛋白酶分泌与脂肪酶和胰蛋白酶分泌的关系。给予标准饮食，并收集粪便48小时。在患者和健康受试者中，比较了十二指肠灌注必需氨基酸（78 mM）和静脉注射胆囊收缩素-胰酶素（0.25 U/kg/min）后的总酶输出。直到脂肪酶输出为正常值的10%或更少时才观察到脂肪酶;同样，只有当胰蛋白酶输出小于正常值的10%时才会发生肌酐。这些关系证明了胰腺外分泌酶分泌的巨大储备能力，并解释了慢性胰腺炎中脂肪酸和肌酐的发展往往较晚。（《新英格兰医学杂志》288：813-815，1973）
To investigate the functioning reserve capacity of the exocrine pancreas, we studied the relations of steatorrhea and creatorrhea to lipase and trypsin outputs in 17 patients with chronic pancreatitis and 33 healthy subjects. A standard diet was given, and stools were collected for 48 hours. Total enzyme outputs in response to duodenal perfusion of essential amino acids (78 mM) and intravenously administered cholecystokinin-pancreozymin (0.25 U per kilogram per minute) were compared in patients and in healthy subjects. Steatorrhea was not observed until lipase output was 10 per cent or less of normal; similarly, creatorrhea occurred only when trypsin outputs were less than 10 per cent of normal. These relations demonstrate the large reserve capacity for enzyme secretion by the exocrine pancreas and explain the often late development of steatorrhea and creatorrhea in chronic pancreatitis. (N Engl J Med 288:813–815, 1973)