Skeletal muscle chemoreflex and pHi in exercise ventilatory control.
Skeletal muscle chemoreflex and pHi in exercise ventilatory control.
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运动通气控制中的骨骼肌化学反射和 pHi。
DOI：
10.1152/jappl.1998.84.2.676
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
Systrom,DM
中科院分区：
文献类型：
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作者：
Oelberg,DA;Evans,AB;Hrovat,MI;Pappagianopoulos,PP;Patz,S;Systrom,DM
Oelberg, David A., Allison B. Evans, Mirko I. Hrovat, Paul P. Pappagianopoulos， Samuel Patz和David M. Systrom。骨骼肌化学反射与pHiin运动通气控制。达成。生理学报，2009(2):676-682,1998。为了确定骨骼肌氢离子是否在运动中调节人体的通气驱动，12名健康受试者在1.5 t磁铁中进行了三次等压次最大股四头肌运动，每2天进行一次，进行31P-MRS。在运动（BLPPex）或恢复（BLPPrec）期间，双侧下肢正压袖带按随机顺序充气至45托，以加强肌肉化学反射。同时测量呼气呼气和分钟通气，动静脉血，以及股内侧肌的31p - mrs，这些数据来自平均12次射频脉冲，重复时间为2.5 s。与BLPPrec相比，BLPPex的运动末期分钟通气量更高（53.3±3.8比37.3±2.2 l/min， P< 0.0001），动脉化更低（33±1比36±1托，P= 0.0009），股四头肌细胞内pH值（pHi）更酸（6.44±0.07比6.62±0.07，P= 0.004）。血乳酸适度增加，但动脉化ph没有变化。对于每个受试者，ph与运动期间的分钟通气呈线性相关，但与动脉化ph无关。这些数据表明，骨骼肌氢离子有助于运动通气反应。
Oelberg, David A., Allison B. Evans, Mirko I. Hrovat, Paul P. Pappagianopoulos, Samuel Patz, and David M. Systrom.Skeletal muscle chemoreflex and pHiin exercise ventilatory control.J. Appl. Physiol.84(2): 676–682, 1998.—To determine whether skeletal muscle hydrogen ion mediates ventilatory drive in humans during exercise, 12 healthy subjects performed three bouts of isotonic submaximal quadriceps exercise on each of 2 days in a 1.5-T magnet for31P-magnetic resonance spectroscopy (31P-MRS). Bilateral lower extremity positive pressure cuffs were inflated to 45 Torr during exercise (BLPPex) or recovery (BLPPrec) in a randomized order to accentuate a muscle chemoreflex. Simultaneous measurements were made of breath-by-breath expired gases and minute ventilation, arterialized venous blood, and by31P-MRS of the vastus medialis, acquired from the average of 12 radio-frequency pulses at a repetition time of 2.5 s. With BLPPex, end-exercise minute ventilation was higher (53.3 ± 3.8 vs. 37.3 ± 2.2 l/min;P< 0.0001), arterializedlower (33 ± 1 vs. 36 ± 1 Torr;P= 0.0009), and quadriceps intracellular pH (pHi) more acid (6.44 ± 0.07 vs. 6.62 ± 0.07;P= 0.004), compared with BLPPrec. Blood lactate was modestly increased with BLPPexbut without a change in arterialized pH. For each subject, pHiwas linearly related to minute ventilation during exercise but not to arterialized pH. These data suggest that skeletal muscle hydrogen ion contributes to the exercise ventilatory response.