Lysosomal mechanisms of tissue injury in arthritis.
Lysosomal mechanisms of tissue injury in arthritis.
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关节炎组织损伤的溶酶体机制。
DOI：
10.1056/nejm197201202860307
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发表时间：
1972
期刊：
影响因子：
--
通讯作者：
G. Weissmann
中科院分区：
文献类型：
--
作者：
G. Weissmann
过去十年的研究表明，溶酶体至少在一定程度上调节了关节的急性和慢性炎症。1 2 3 4这种联系并不意味着已经在人类关节炎中发现了病原体，除非是在晶体诱导或感染性关节炎这样的离散实体中。然而，有两个要点得到了赞赏。首先，很明显，溶酶体中的物质会引起炎症、组织损伤和结缔组织的破坏。其次，作为DeDuve所描述的“空泡器”的一部分，溶酶体的正常功能是将酶从细胞中排出到周围组织中。很久以前。
STUDIES during the past decade have indicated that lysosomes mediate, at least in part, acute and chronic inflammation in joints.1 2 3 4 This association in no way implies that etiologic agents have been identified in human arthritis, except in such discrete entities as crystal-induced or infectious arthritis. Two main points have been appreciated, however. First of all, it is clear that materials present in lysosomes can provoke inflammation, tissue injury and breakdown of connective tissue. Secondly, it is the normal function of lysosomes, as part of the "vacuolar apparatus" described by DeDuve,5 to extrude enzymes from cells into surrounding tissues. Since many . . .