What is personalized medicine and what should it replace?
What is personalized medicine and what should it replace?
复制标题
DOI：
10.1038/nrgastro.2012.100
复制
发表时间：
2012-07-01
影响因子：
65.1
通讯作者：
Whitcomb, David C.
中科院分区：
文献类型：
--
作者：
Whitcomb, David C.
个性化医疗是一种新的医疗框架，涉及根据疾病的潜在机制对其进行建模和模拟。这一战略必须取代20世纪世纪通过病理学或相关体征和症状定义疾病的范式，并根据疾病综合征的存在或不存在进行结果研究。新技术，包括下一代测序，“组学”和强大的计算机提供了大量的准确数据。然而，试图通过在世纪的框架内应用这些新技术来理解复杂的疾病，却未能产生预期的医学进步。为了帮助医生接受范式转变，旧框架的局限性和新框架的主要优势必须得到证明。慢性胰腺炎是一种理想的复杂疾病，要考虑两种框架的利弊来研究，因为胰腺是一个如此简单的器官进行疾病建模，而个性化医疗的优势又是如此深刻。
Personalized medicine is a new framework for medical care that involves modelling and simulation of a disease on the basis of its underlying mechanisms. This strategy must replace the 20th century paradigm of defining disease by pathology or associated signs and symptoms and conducting outcomes research that is based on the presence or absence of the disease syndrome. New technologies, including next-generation sequencing, the 'omics' and powerful computers provide massive amounts of accurate data. However, attempts to understand complex disorders by applying these new technologies within the 20th century framework have failed to produce the expected medical advances. To help physicians embrace a paradigm shift, the limitations of the old framework and major advantages of the new framework must be demonstrated. Chronic pancreatitis is an ideal complex disorder to study to consider the pros and cons of the two frameworks, because the pancreas is such a simple organ for disease modelling, and the advantages of personalized medicine are so profound.