Effect of chemokine receptor mutations on heterosexual human immunodeficiency virus transmission
Effect of chemokine receptor mutations on heterosexual human immunodeficiency virus transmission
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DOI：
10.1086/314918
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发表时间：
1999-09-01
影响因子：
6.4
通讯作者：
Brown, AJL
中科院分区：
文献类型：
--
作者：
Lockett, SF;Alonso, A;Brown, AJL
为探讨CCR-2和CCR-5基因突变对人类免疫缺陷病毒(HIV)异性传播的影响，对144名异性接触者(感染和未感染)和57名HIV阳性指标伴侣进行了基因分型，发现HIV阳性患者CCR-2基因64I杂合子频率显著高于欧盟女性(P=0.02，相对风险=1.6)。女性HIV阳性接触者64I等位基因频率为8%，EU为1%(P<0.05)。
To assess the effect of mutations at the CCR-2 and CCR-5 loci on heterosexual human immunodeficiency virus (HIV) transmission, 144 persons heterosexually exposed to HIV (infected and uninfected [EU]) and 57 HIV-positive index partners were genotyped, A significantly higher frequency of 64I heterozygotes at CCR-2 was observed in HIV-positive than in EU women (P = .02, relative risk = 1.6). The allele frequency of 64I in women was 8% in HIV-positive contacts and 1% in EUs (P