A pH-Responsive DNAsome from the Self-Assembly of DNA-Phenyleneethynylene Hybrid Amphiphile
A pH-Responsive DNAsome from the Self-Assembly of DNA-Phenyleneethynylene Hybrid Amphiphile
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DOI：
10.1002/chem.201701446
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发表时间：
2017-06-22
影响因子：
4.3
通讯作者：
Varghese, Reji
中科院分区：
文献类型：
--
作者：
Albert, Shine K.;Golla, Murali;Varghese, Reji
报道了一种pH响应性DNA小体，它是由含有富C DNA序列的DNA两亲物在两亲性驱动下自组装而成的。DNA小体的酸化导致富含C的DNA从无规卷曲到i-motif结构的结构变化，从而引发DNA小体的解体及其随后的形态转化为开放的缠结网络。还证明了疏水客体包封到DNA体的膜中以及其在DNA体酸化时的pH触发释放。
A pH-responsive DNAsome derived from the amphiphilicity-driven self-assembly of DNA amphiphile containing C-rich DNA sequence is reported. The acidification of DNAsome induces a structural change of C-rich DNA from random coil to an i-motif structure that triggers the disassembly of DNAsome and its subsequent morphological transformation into an open entangled network. The encapsulation of a hydrophobic guest into the membrane of DNAsome and its pH-triggered release upon acidification of DNAsome is also demonstrated.