Benign course and clinical features of COVID-19 in hospitalised febrile infants up to 60 days old
Benign course and clinical features of COVID-19 in hospitalised febrile infants up to 60 days old
复制标题
DOI：
10.1111/apa.15993
复制
发表时间：
2021-06-30
期刊：
影响因子：
3.8
通讯作者：
Livni, Gilat
中科院分区：
文献类型：
--
作者：
Yarden Bilavski, Havazelet;Balanson, Sarit;Livni, Gilat
关于COVID-19在60天以下发热婴儿中的严重程度的数据很少。这项多中心前瞻性研究探讨了这一住院患者人群的临床病程和结局，因为迄今为止，尚未具体说明最佳方法。方法本研究重点关注2020年3月至2021年1月期间在以色列住院的60天内病毒检测呈阳性的发热婴儿的临床特征、实验室参数和结局。这些数据是从COVID-19的实时前瞻性监测网络中提取的，该网络包括该国26家医院中的20家。结果我们确定了75名患有COVID-19的发热幼儿（60%为女性），中位年龄为28天（范围为8-56天）。其中，84%的人有不明显的病史，29%的人有呼吸道症状，96%的人有轻微疾病。罗切斯特标准显示，44%的婴儿被认为是严重细菌感染的高危人群，我们发现有8名婴儿实际上伴有细菌感染。结局极佳，未报告并发症或死亡。结论COVID-19引起的年轻发热婴儿的良好结局与该年龄组其他呼吸道病毒引起的发热密切相关，无死亡病例。
Aim Minimal data exist regarding the severity of COVID-19 in febrile infants under 60 days old. This multicentre prospective study explored the clinical course and outcomes of this hospitalised patient population, as, to date, the best approach has not been specifically addressed. Methods This study focused on the clinical features, laboratory parameters and outcomes of febrile infants up to 60 days old who tested positive for the virus and were hospitalised in Israel from March 2020 to January 2021. The data were extracted from a real-time prospective surveillance network for COVID-19 that includes 20 of the country's 26 hospitals. Results We identified 75 febrile young infants (60% female) with COVID-19 at a median age of 28 days (range 8-56 days). Of these, 84% had an unremarkable medical history, 29% had respiratory symptoms, and 96% had a mild illness. The Rochester criteria showed that 44% were considered at high-risk for serious bacterial infections, and we found that eight infants actually had concomitant bacterial infections. Outcomes were excellent, and no complications or fatalities were reported. Conclusion The excellent outcomes of young febrile infants with COVID-19 closely resembled other respiratory viral aetiologies of fever in this age group, and there were no fatalities.