Involvement of sodium retention hormones during rehydration in humans.
Involvement of sodium retention hormones during rehydration in humans.
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人类补液过程中钠潴留激素的参与。
DOI：
10.1152/jappl.1988.65.1.332
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Nadel,ER
中科院分区：
文献类型：
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作者：
Nose,H;Mack,GW;Shi,XR;Nadel,ER
我们研究了非自愿脱水与影响体内Na+滞留的机制的关系，重点是肾素-血管紧张素-醛固酮系统。6名成年男性通过运动-热疗方案脱水至体重的2.3%，然后用自来水(H2O-R)或0.45%氯化钠溶液(Na-R)复水180min。我们测定了脱水前(对照组)、脱水后、复水60、120和180分钟的血浆肾素活性(PRA)和醛固酮水平(PA)。在3h复水期间，受试者恢复了在H2O-R和Na-R过程中失水的51%和71%(P<0.05)。脱水后血浆体积平均减少4.5%。复水180min后，Na-R时血浆容量恢复至失血时的174%，H2O-R时为失血时的78%。血浆容量变化与血浆肾素活性呈显著负相关(r=-0.70P<0.001)，与血浆蛋白原呈显著正相关(r=0.71P<0.001)。在两种恢复状态下，PRA在脱水后显著升高(P<0.05)，在复水180min时几乎降至对照水平，此时血浆容量赤字已恢复。PA的变化与PRA的变化平行。两组钠排泄率与PA水平呈正相关(r=-0.58，P<0.01)。
We investigated the relation between involuntary dehydration and the mechanisms affecting Na+ retention in the body, focusing on the renin-angiotensin-aldosterone system. Six adult males were dehydrated to 2.3% of their body weight by an exercise-heat regimen, followed by rehydration (180 min) with tap water (H2O-R) or 0.45% NaCl solution (Na-R). We measured plasma renin activity (PRA) and aldosterone levels (PA) before dehydration (control), after dehydration, and at 60, 120, and 180 min of rehydration. During the 3-h rehydration period, subjects, restored 51% of the water lost during H2O-R and 71% during Na-R (P less than 0.05). Plasma volume was reduced by an average of 4.5% after dehydration. After 180 min of rehydration, plasma volume restoration during Na-R was to 174% of that lost, and during H2O-R it was to 78% of that lost. We found significant correlations between the change in plasma volume and PRA (r = -0.70, P less than 0.001) and between PRA and PA (r = 0.71, P less than 0.001). In both recovery conditions, PRA increased significantly after dehydration (P less than 0.05) and decreased almost to the control level by 180 min of rehydration, at which time the plasma volume deficit was restored. The change in PA paralleled that in PRA. The rate of sodium excretion was correlated with PA levels in both groups (r = -0.58, P less than 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)