The ETS1 transcription factor is required for the development and cytokine-induced expansion of ILC2.
The ETS1 transcription factor is required for the development and cytokine-induced expansion of ILC2.
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DOI：
10.1084/jem.20150851
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发表时间：
2016-05-02
期刊：
影响因子：
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通讯作者：
Kee BL
中科院分区：
文献类型：
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作者：
Zook EC;Ramirez K;Guo X;van der Voort G;Sigvardsson M;Svensson EC;Fu YX;Kee BL
Zook et al. use a novel mouse model to demonstrate a requirement for the transcription factor ETS1 in the development and function of group 2 innate lymphoid cells. Group 2 innate lymphoid cells (ILC2s) are a subset of ILCs that play a protective role in the response to helminth infection, but they also contribute to allergic lung inflammation. Here, we report that the deletion of the ETS1 transcription factor in lymphoid cells resulted in a loss of ILC2s in the bone marrow and lymph nodes and that ETS1 promotes the fitness of the common progenitor of all ILCs. ETS1-deficient ILC2 progenitors failed to up-regulate messenger RNA for the E protein transcription factor inhibitor ID2, a critical factor for ILCs, and these cells were unable to expand in cytokine-driven in vitro cultures. In vivo, ETS1 was required for the IL-33–induced accumulation of lung ILC2s and for the production of the T helper type 2 cytokines IL-5 and IL-13. IL-25 also failed to elicit an expansion of inflammatory ILC2s when these cells lacked ETS1. Our data reveal ETS1 as a critical regulator of ILC2 expansion and cytokine production and implicate ETS1 in the regulation of Id2 at the inception of ILC2 development.
