QINGHAOSU (ARTEMISININ) - AN ANTIMALARIAL DRUG FROM CHINA
QINGHAOSU (ARTEMISININ) - AN ANTIMALARIAL DRUG FROM CHINA
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DOI：
10.1126/science.3887571
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发表时间：
1985-01-01
期刊：
影响因子：
56.9
通讯作者：
KLAYMAN, DL
中科院分区：
文献类型：
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作者：
KLAYMAN, DL
青蒿在中国传统医学中作为治疗发烧和疟疾的药物已经使用了许多世纪。1971年，中国的化学家们从这种植物的叶子中分离出了一种物质，这种物质被认为具有药用作用。这种化合物，被称为青蒿素（QHS，青蒿素），是一种带有过氧化物基团的倍半萜内酯，与大多数其他抗疟药不同，它缺乏含氮杂环系统。该化合物已成功用于中国数千名疟疾患者，包括那些对氯喹敏感和对氯喹耐药的恶性疟原虫菌株。QHS的衍生物，如二氢青蒿素、蒿甲醚和水溶性青蒿琥酯钠，似乎比QHS本身更有效。青蒿琥酯钠对脑型疟疾昏迷患者的促醒作用迅速。因此，QHS及其衍生物作为一种全新的抗疟药提供了希望。
The herbArtemisia annuahas been used for many centuries in Chinese traditional medicine as a treatment for fever and malaria. In 1971, Chinese chemists isolated from the leafy portions of the plant the substance responsible for its reputed medicinal action. This compound, calledqinghaosu(QHS, artemisinin), is a sesquiterpene lactone that bears a peroxide grouping and, unlike most other antimalarials, lacks a nitrogen-containing heterocyclic ring system. The compound has been used successfully in several thousand malaria patients in China, including those with both chloroquine-sensitive and chloroquine-resistant strains ofPlasmodium falciparum. Derivatives of QHS, such as dihydroqinghaosu, artemether, and the water-soluble sodium artesunate, appear to be more potent than QHS itself. Sodium artesunate acts rapidly in restoring to consciousness comatose patients with cerebral malaria. Thus QHS and its derivatives offer promise as a totally new class of antimalarials.