Cladomarine, a new anti-saprolegniasis compound isolated from the deep-sea fungus, Penicillium coralligerum YK-247
Cladomarine, a new anti-saprolegniasis compound isolated from the deep-sea fungus, Penicillium coralligerum YK-247
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DOI：
10.1038/ja.2017.58
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发表时间：
2017-08-01
影响因子：
3.3
通讯作者：
Omura, Satoshi
中科院分区：
文献类型：
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作者：
Takahashi, Konami;Sakai, Kazunari;Omura, Satoshi
水霉科（Saprolegniaceae）属于卵菌门（Oomycota），其中寄生水霉（Saprolegnia parasitica）是鱼类及其卵的致病菌，在淡水养殖业中造成巨大的破坏和损失，1，2如鲑鱼孵化场。在养鱼场，水霉病已被孔雀石绿色控制，有效地防止了感染。然而，孔雀石绿色已被禁止在许多国家，因为它被发现是诱变。溴硝丙二醇有时被用作抗水霉病剂的替代品，但不如孔雀石绿色有效，并且对浮游动物和浮游植物有毒。3、4因此，迫切需要新的抗水霉病化合物。真菌是有用化合物和真菌毒素的丰富来源，经常被探索以发现新的有用物质。真菌栖息在各种环境中，从陆地到海洋。值得注意的是，尽管深海环境的条件具有高压、低温和寡养的特点，但深海环境中存在着各种各样的真菌。5、6极端条件可能影响深海真菌初级和次级代谢产物的产生，因此，它们很可能产生结构和功能独特的代谢产物。7事实上，越来越多地报道深海真菌产生的新的生物活性次级代谢物。8–10
The Saprolegniaceae belongs to the Oomycota; among a member of this family, Saprolegnia parasitica is a virulent pathogen of fishes and their ova, and causes enormous damage and losses in the freshwater aquaculture, 1, 2 such as a salmon hatchery. In fish farms, saprolegniasis has been controlled by malachite green, effectively preventing infection. However, malachite green has been banned in many countries because it was found to be mutagenic. Bronopol is sometimes used as an alternative anti-saprolegniasis agent, but is not as effective as malachite green and is toxic to zooplankton and phytoplankton. 3, 4 Therefore, new anti-saprolegniasis compounds are urgently needed.Fungi are rich sources of useful chemical compounds and mycotoxins, and are often explored to discover new useful substances. The fungi inhabit various environments, from land to sea. Remarkably, diverse fungi are present in deep-sea environments, in spite of the fact that the conditions in deep-sea environments are characterized by high pressure, low temperature and oligotrophy. 5, 6 The extreme conditions may affect the production of primary and secondary metabolites in deep-sea fungi, and therefore, there is a high probability that they produce structurally and functionally unique metabolites. 7 Indeed, novel bioactive secondary metabolites from deep-sea fungi are increasingly being reported. 8–10