MiR-361-5p acts as a tumor suppressor in prostate cancer by targeting signal transducer and activator of transcription-6(STAT6)
MiR-361-5p acts as a tumor suppressor in prostate cancer by targeting signal transducer and activator of transcription-6(STAT6)
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MiR-361-5p 通过靶向信号转导器和转录 6 (STAT6) 激活剂在前列腺癌中充当肿瘤抑制因子
DOI：
10.1016/j.bbrc.2014.01.140
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发表时间：
2014-02-28
影响因子：
3.1
通讯作者：
Chen, Ming
中科院分区：
文献类型：
--
作者：
Liu, Dachuang;Tao, Tao;Chen, Ming
去势抵抗性前列腺癌（CRPC）的发病机制已知受microRNA（miRNAs）调控，预后不良。在本研究中，我们发现miR-361- 5 p在CRPC中的表达低于雄激素依赖性前列腺癌（ADPC），表明miR-361- 5 p可能在ADPC向CRPC的进展中发挥重要作用。miR-361- 5 p在前列腺癌（PCa）中的作用迄今尚未评估。我们的研究结果表明，miR-361- 5 p是CRPC的抑制因子。miR-361- 5 p的直接靶点信号转导子和转录激活子-6（STAT 6）可增强超大型B细胞淋巴瘤（Bcl-xL）的表达，而miR-361- 5 p通过STAT 6抑制其表达。因此，miR-361- 5 p在预防PCa恶性进展中具有重要的临床意义。(C)2014 Elsevier Inc. All rights reserved.
Castration-resistant prostate cancer (CRPC), whose pathogenesis is known to be regulated by microRNAs (miRNAs), has a poor prognosis. In our present study, we found that the expression of miR-361-5p in CRPC was lower than in androgen-dependent prostate cancer (ADPC), indicating that miR-361-5p may play an important role in the progression of ADPC to CRPC. The role of miR-361-5p in prostate cancer (PCa) has not been evaluated until date. Our findings suggest that miR-361-5p is a suppressor in CRPC. Signal transducer and activator of transcription-6 (STAT6), a direct target of miR-361-5p, enhances the expression of B-cell lymphoma-extra large (Bcl-xL), while miR-361-5p inhibits its expression through STAT6. Therefore, miR-361-5p has great clinical significance in preventing the malignant progression of PCa. (C) 2014 Elsevier Inc. All rights reserved.