Barrel rotation induced by vasopressin and involvement of dopaminergic and cholinergic functions in rats.
Barrel rotation induced by vasopressin and involvement of dopaminergic and cholinergic functions in rats.
复制标题
加压素诱导的桶旋转以及大鼠多巴胺能和胆碱能功能的参与。
DOI：
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发表时间：
1981
影响因子：
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通讯作者：
T. Furukawa
中科院分区：
文献类型：
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作者：
K. Yamada;T. Furukawa
脑室注射1，6-氨基辛二酰-精氨酸-加压素或生长抑素可引起大鼠桶形旋转，一种沿着矢状体轴的特殊旋转。氟奋乃静、氟哌啶醇、6-羟基多巴胺或α-甲基-p-酪氨酸可显著增强加压素诱导的桶旋转，但不受（D-Ala 2、MePhe 4、Met（O）5-ol）-脑啡肽的影响。用毒蕈碱受体阻断剂苯海索预处理可阻止氟奋乃静旋转行为的增强。这些观察结果清楚地表明，加压素可以引起桶旋转，多巴胺能抑制和胆碱能激活伴随参与。
Intraventricular administration of 1,6-aminosuberyl-arginine8-vasopressin or somatostatin in rats barrel rotation, a peculiar rotation along the sagittal body axis. The vasopressin-induced barrel rotation was markedly enhanced by fluphenazine, haloperidol, 6-hydroxydopamine or alpha-methyl-p-tyrosine but was unaffected by (D-Ala2, MePhe4, Met(O)5-ol)-enkephalin. The enhancement of the rotation behavior of fluphenazine was prevented by pretreatment with trihexy-phenidyl a muscarinic receptor blocker. These observations clearly show that vasopressin can elicit barrel rotation and that dopaminergic inhibition and cholinergic activation are concomitantly involved.