NFAT gene family in inflammation and cancer.
NFAT gene family in inflammation and cancer.
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DOI：
10.2174/1566524011313040007
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发表时间：
2013-05
影响因子：
2.5
通讯作者：
Chen F
中科院分区：
文献类型：
--
作者：
Pan MG;Xiong Y;Chen F
钙调神经磷酸酶-NFAT 信号传导对于胚胎发育期间和之后脊椎动物功能的许多方面都至关重要。 NFAT基因家族最初在T细胞中发现，由五个成员组成，调节免疫系统、炎症反应、血管生成、心脏瓣膜形成、心肌发育、轴突导向、骨骼肌发育、骨稳态、癌症的发展和转移以及许多其他生物过程。在这篇综述中，我们将重点关注与炎症和癌症这两个密切相关的病理系统相关的 NFAT 文献。
Calcineurin-NFAT signaling is critical for numerous aspects of vertebrate function during and after embryonic development. Initially discovered in T cells, the NFAT gene family, consisting of five members, regulates immune system, inflammatory response, angiogenesis, cardiac valve formation, myocardial development, axonal guidance, skeletal muscle development, bone homeostasis, development and metastasis of cancer, and many other biological processes. In this review we will focus on the NFAT literature relevant to the two closely related pathological systems: inflammation and cancer.