Isolation of an anthelmintic compound from Leucosidea sericea
Isolation of an anthelmintic compound from Leucosidea sericea
复制标题
DOI：
10.1016/s0254-6299(15)30189-7
复制
发表时间：
2004-10-01
影响因子：
3.1
通讯作者：
McCrindle, R
中科院分区：
文献类型：
--
作者：
Bosman, AA;Combrinck, S;McCrindle, R
Leucosidea sericea（蔷薇科）的叶子被一些南非土著人用作驱虫剂和收敛剂。在文献中找不到关于该植物的生物活性和植物化学的信息。生物测定引导的分级分离用于鉴定活性化合物。部分纯化的叶和花的石油醚提取物，然后通过使用色谱法进行分级分离。该过程产生间苯三酚衍生物，aspidinol和desaspidinol，其先前报道存在于鳞毛蕨属物种中。Aspidinol被进一步分离和结构解析。这是首次报道这些化合物存在于绢毛白甙中。采用纸片扩散法测定了该植物对金黄色葡萄球菌、枯草芽孢杆菌和白色念珠菌的抑菌活性。
The leaves of Leucosidea sericea (Rosaceae) are used medicinally by some indigenous South African people as a vermifuge and astringent. No information on the biological activity and phytochemistry of the plant could be found in the literature. Bioassay-guided fractionation was used to identify the active compound. Partial purification of the petroleum ether extract of the leaves and flowers was followed by fractionation using chromatographic methods. This process yielded the phloroglucinol derivatives, aspidinol and desaspidinol, which were previously reported to be present in a Dryopteris species. Aspidinol was further isolated and structurally elucidated. This is the first report of the presence of these compounds in Leucosidea sericea. The disk diffusion method used in our study, indicated that the plant has antimicrobial activity against Staphylococcus aureus, Bacillus subtilis and Candida albicans.