Cognitive reserve associated with FDG-PET in preclinical Alzheimer disease
Cognitive reserve associated with FDG-PET in preclinical Alzheimer disease
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DOI：
10.1212/wnl.0b013e31828970c2
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发表时间：
2013-03-01
期刊：
影响因子：
9.9
通讯作者：
Weiner, Michael W.
中科院分区：
文献类型：
--
作者：
Ewers, Michael;Insel, Philip S.;Weiner, Michael W.
目的：探讨教育（认知储备的替代指标）对老年认知健康（HC）阿尔茨海默病（AD）患者FDG-PET脑代谢的影响。方法：52名HC受试者（平均年龄75岁），FDG-PET和脑脊液A β(1-42)测量均来自阿尔茨海默病神经影像学倡议生物标志物前瞻性研究。HC受试者接受临床前AD的研究分类，如果CSF a β(1-42)为
Objective: To examine the effect of education (a surrogate measure of cognitive reserve) on FDG-PET brain metaolism in elderly cognitively healthy (HC) subjects with preclinical Alzheimer disease (AD).Methods: Fifty-two HC subjects (mean age 75 years) with FDG-PET and CSF measurement of A beta(1-42) were included from the prospective Alzheimer's Disease Neuroimaging Initiative biomarker study. HC subjects received a research classification of preclinical AD if CSF A beta(1-42) was