Is the Alzheimer's disease cortical thickness signature a biological marker for memory?
Is the Alzheimer's disease cortical thickness signature a biological marker for memory?
复制标题
DOI：
10.1007/s11682-015-9413-5
复制
发表时间：
2016-06
影响因子：
3.2
通讯作者：
Brickman AM
中科院分区：
文献类型：
--
作者：
Busovaca E;Zimmerman ME;Meier IB;Griffith EY;Grieve SM;Korgaonkar MS;Williams LM;Brickman AM
最近的研究表明，对关键脑区皮质厚度的分析可用于识别患阿尔茨海默病（AD）风险最大的个体。然而，目前还不清楚这种“签名”在多大程度上是正常记忆功能的生物标志物-受AD影响的主要认知领域。我们在一组神经健康的年轻人和老年人中研究了AD特征生物标志物和记忆功能之间的关系。皮质厚度测量和神经心理学评价获得了110名成年人（年龄范围21 - 78，平均= 46）从脑资源国际数据库。队列分为年轻成人（n = 64，年龄21 - 50）和老年成人（n = 46，年龄51 - 78）组。使用FreeSurfer进行皮质厚度分析，并从构成AD特征的八个区域中提取平均皮质厚度。我们研究了AD特征皮质厚度和记忆之间的关系，并测试了这种关系是否随年龄组而变化。平均AD-签名皮质厚度与列表学习任务的延迟自由回忆试验的表现呈正相关，这种关系在年轻人和老年人之间没有差异。在两组中，平均AD特征皮层厚度与作为对照任务的心理速度测试的表现无关。结果表明，AD特征皮质厚度是整个成年期记忆功能的标志。
Recent work suggests that analysis of the cortical thickness in key brain regions can be used to identify individuals at greatest risk for development of Alzheimer’s disease (AD). However, it is unclear to what extent this “signature” is a biological marker of normal memory function – the primary cognitive domain affected by AD. We examined the relationship between the AD signature biomarker and memory functioning in a group of neurologically healthy young and older adults. Cortical thickness measurements and neuropsychological evaluations were obtained in 110 adults (age range 21–78, mean=46) drawn from the Brain Resource International Database. The cohort was divided into young adult (n=64, age 21–50) and older adult (n=46, age 51–78) groups. Cortical thickness analysis was performed with FreeSurfer, and the average cortical thickness extracted from the eight regions that comprise the AD signature. We examined the relationship between AD-signature cortical thickness and memory, and tested whether this relationship varies as a function of age group. Mean AD-signature cortical thickness was positively associated with performance on the delayed free recall trial of a list learning task and this relationship did not differ between younger and older adults. Mean AD-signature cortical thickness was not associated with performance on a test of psychomotor speed, as a control task, in either group. The results suggest that the AD signature cortical thickness is a marker for memory functioning across the adult lifespan.