Potential Influence of Body Weight on the Clearance of Polymorphically Acetylated Drugs

Potential Influence of Body Weight on the Clearance of Polymorphically Acetylated Drugs
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体重对多晶型乙酰化药物清除的潜在影响

DOI：
10.1002/j.1552-4604.1982.tb02673.x
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发表时间：
1982
期刊：
The Journal of Clinical Pharmacology
影响因子：
--
通讯作者：
Susan A. Mercik
Susan A. Mercik
中科院分区：
--
文献类型：
--
作者：
D. Chapron;P. Kramer;Susan A. Mercik

文献摘要

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摘要：研究发现，在中间和快速乙酰化器中，磺胺二甲嘧啶的乙酰化清除量显著依赖于体重。在快速乙酰化器中，乙酰化清除率与体重的相关性更强。建议在为表型目的构建分布直方图时使用加权校正的乙酰化清除值。在表型模式中，体重在提供剂量需求的初步估计时可能是有用的。
Abstract: The acetylation clearance of sulfamethazine was found to be significantly dependent upon body weight in both intermediate and rapid acetylators. The correlation beween acetylation clearance and body weight was stronger in the rapid acetylator. It is recommended that weight‐corrected acetylation clearance values be used when constructing distribution histograms for phenotyping purposes. Within a phenotypic mode, body weight may be useful in providing initial estimates of dosing needs.